1,563 zoekresultaten voor “fake news disinformation” in de Publieke website
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Mononuclear spin-transition materials based on the bapbpy scaffold
Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Combining monitoring with run-time assertion checking
Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue
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Abiotic depletion in LCIA
Possible improvements for the assessment of abiotic depletion in LCA.
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Probing the properties of dark matter particles with astrophysical observations
It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Exploring future multi-messenger Galactic astronomy
For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.
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Mechanical metamaterials: nonlinear beams and excess zero modes
Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.
- Summer School: "Manuscript Studies: Codicology and Digital Techniques" (5 ECTS)
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Student for a day Philosophy: Global and Comparative Perspectives
Studievoorlichting
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Wetenschap buiten de kantoormuren: quantum op een festival of in de bieb.
Promovendus Vincent Koeman wil dat echt iedereen met quantum in aanraking komt. Hoe hij dat doet? Met een quantum pop-up tentoonstelling in de lokale bibliotheek én op Lowlands Science. Hij vertelt erover in het Leidsch Dagblad en New Scientist.
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Waarom moet collectief leren in de praktijk hersteld worden?
Jet Bussemaker, hoogleraar Wetenschap, beleid en maatschappelijke impact in de zorg, schrijft over het herstellen van collectief leren in de praktijk
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Tracing the evolution of protoplanetary disks
Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)
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Learning class-imbalanced problems from the perspective of data intrinsic characteristics
The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.
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Gravitational waves through the cosmic web
The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.
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Spectropolarimetry for planetary exploration
Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik
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Assessing the link between television consumption and the attitudes toward people living with HIV/AIDS in Chile
We analyse the link between media consumption and the attitudes toward people living with HIV/AIDS in Chile. We used data from a sample of 1000 people, obtained in the 2011 wave of the World Values Survey (WVS). We use a logistic binary regression model by maximum likelihood. Our results suggest that…
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Electrocatalytic reduction of CO2 and nitrate on immobilized metal porphyrins
M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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CO oxidation catalysis at multiple length scales
Promotor: J.W.M. Frenken Co-Promotor: R. Felici
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Resource allocation in networks via coalitional games
Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone
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De rol van onderzoek in universitair onderwijs: Chinese en Nederlandse docenten vergeleken
Universitair docenten spelen een belangrijke rol bij het opwekken van interesse voor onderzoek bij hun studenten. In dit onderzoek worden de opvattingen van Chinese en Nederlandse docenten over de rol van onderzoek in het onderwijs bekeken. Hoe kunnen deze opvattingen worden verklaard vanuit de culturele…
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Symposia
De Leiden Teachers’ Academy organiseert jaarlijks een symposium over onderwijsvernieuwing aan de Universiteit Leiden.
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Terugblik op de World Press Freedom Conference door Leidsch Dagblad
Tijdens de World Press Freedom Conference van 9 en 10 december deelde een dertigtal academici de resultaten van hun onderzoek naar persvrijheid. Het Leidsch Dagblad blikte terug op het evenement.
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Postdoc in Comparative Political Economy of Labour Market Risks and Welfare State Transformations
Rechtsgeleerdheid
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Debat over de toekomst van soft power practices in Washington DC
Op 6 juni jl. lanceerde het The Hague Journal of Diplomacy in Washington DC zijn meest recente speciale dubbele editie: ‘Debating Public Diplomacy: Now and Next over de toekomst van soft power practices. Het seminar werd gehouden in het Pew Research Center, dat bekend staat om zijn wereldwijde opiniepeilingen.…
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‘Laat leerlingen actief met teksten omgaan om hun leesbegrip te verbeteren’
De leesvaardigheid van Nederlandse jongeren daalt al jaren. De voornaamste oorzaak voor die afname is dat veel leerlingen moeite hebben met verdiepend lezen. Leer leerlingen om teksten actief te lezen, en om zo bezig te zijn met het construeren van betekenis. Dat schrijven de Leidse onderzoekers Paul…
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Nieuwe lezingenreeks Letter en Geest: Neerlandistiek in Leiden
Vanuit de opleiding Nederlandse taal en cultuur biedt de Universiteit Leiden een gloednieuwe lezingenreeks aan: Letter en Geest: Neerlandistiek in Leiden. De reeks combineert bestaande en nieuwe lezingen. Naast de jaarlijkse Indische Letterenlezing en Albert Verweylezing worden docenten, alumni en…
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Carbon4PUR | Turning industrial waste gases (mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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Special edition Information Polity
In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.
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Nonparametric Bayesian Methods in Robotic Vision
In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.
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SiTaSol
What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Career
The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.
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Coherent dynamics in solar energy transduction
Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
- Nieuwsbrief
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Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.
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Statistical learning for complex data to enable precision medicine strategies
Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.
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From intracluster medium dynamics to particle acceleration
The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt