194 zoekresultaten voor “genome organization” in de Publieke website
-
The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
-
Leiden Genome Technology Center
De faciltieit ontwikkelt en gebruikt, high-throughputmethoden toe voor genomisch onderzoek.
-
Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
-
Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
-
Unfolding the principles of genome folding and dynamics in bacteria
Remus Dame
-
applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
-
Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
-
engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
-
The mechanical genome : inquiries into the mechanical function of genetic information
The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.
-
Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
-
Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
-
Unraveling Determinants of Inclusive Leadership in Public Organizations
In dit artikel onderzoekt Tanachia Ashikali de determinanten van inclusief leiderschap.
-
and neoplastic B cells: From AID- induced diversification to genome-wide patterns
Promotie
-
investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
-
A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
-
The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
-
regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based metabolomics approach
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
-
'The Love for International Organizations'
Een conferentie georganiseerd door Niels Blokker, hoogleraar Internationaal Institutioneel Recht en Ramses Wessel (RUG) ter viering van de 20e verjaardag van het tijdschrift International Organizations Law Review
-
Using Agent-Level Factors to Explain Variation in Human Rights Promotion Strategies
In dit artikel stelt Tom Buitelaar een systematisch kader voor om het effect van individuele kenmerken van vredeshandhavers op het gedrag van grondpersoneel bij VN-vredesoperaties te analyseren.
-
Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
-
International Labour Organization: tumult op de wereldwijde arbeidsmarkt
Al sinds 1919 strijdt de International Labour Organization (ILO) voor de rechten van werkenden wereldwijd. De Universiteit Leiden is op 7 februari gastvrouw van het symposium waarmee de ILO haar 100-jarig bestaan viert. De Leidse emeritus hoogleraar Internationaal Arbeidsrecht Paul van der Heijden was…
-
Jaap Reijling
Faculteit Governance and Global Affairs
j.reijling@fgga.leidenuniv.nl | +31 70 800 9400
-
Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
-
Solvent tolerance mechanisms in Pseudomonas putida
Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.
-
Resolving a bioindicator diatom species complex using genomic approaches for freshwater biomonitoring
This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;
-
Sculpting the genome and beyond
Promotie
-
Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
-
Functional study of the human genome
Promotie
-
CRISPR Cas-induced targeted mutagenesis with Agrobacterium mediated protein delivery
The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.
-
Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
-
Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
-
Michiel Veldhuis
Wiskunde en Natuurwetenschappen
m.p.veldhuis@cml.leidenuniv.nl | +31 71 527 1494
-
Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
-
Postdoc: Algorithmic developments to automatically detect RiPP structural features
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
-
Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
-
Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
-
Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
-
A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
-
Safeguarding genome integrity with small ubiquitin-like modifers
Promotie
-
Engagement of citizens and public professionals in the co-production of public services
The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…
-
Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
-
Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
-
Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
-
Soft genome editing based on CRISPR nickases: it takes one break to tango
Promotie
-
Governance of Innovation Project Management: Necessary and Neglected
Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries
-
Interactions from lipid membrane deformations
Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.
-
Women Writing Mexico (WWM)
Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…
-
Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
-
Identification and characterization of viral Xrn1-resistant RNAs
Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas