152 zoekresultaten voor “title therapy” in de Publieke website
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
- From basic research to therapy development for neuromuscular disorders
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Exercise therapy in people with rheumatoid arthritis and severe functional disability
Promotie
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cure: Towards Improving Hematopoietic stem cell based lentiviral gene therapy
Promotie
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Publicaties
Lees meer over selectief mutisme
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Promotie 'Art therapy & Anxiety' Annemarie Madani-Abbing
Op 22 januari 2020 verdedigt Annemarie Madani-Abbing haar proefschrift 'Art Therapy & Anxiety'.
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The Metallophilic Interaction between Cyclometalated Complexes: Photobiological Applications
In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Haico van AttikumFaculteit Geneeskunde
h.van.attikum@lumc.nl | +31 71 526 9624
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Preclinical therapy development in FSHD
Promotie
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Immuno-photodynamic therapy of cancer
Promotie
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LCN2 seminar November 2024
Lezing
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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GMP-faciliteit voor innovatieve geneesmiddelen (KFT-J10 / IGFL)
De GMP-faciliteit maaktde ontwikkeling en productie van Advanced Therapy Medicinal Products (ATMP's) en chemische (peptide) synthese mogelijk.
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Rare-earth nanoparticles in bioimaging and therapy
Promotie
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Antithrombotic therapy in the Netherlands- New insights from nationwide data
Promotie
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Clinical pharmacometrics to optimize immunosuppressive therapy in kidney transplantation
Promotie
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Viral gene therapy approaches for CRB1 retinal disease
Promotie
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Immune modulation and monitoring of cell therapy in inflammatory disorders
Promotie
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Nieuwe hoogleraar wil betere zorg door app voor sarcoompatiënten
Artsen moeten samen met patiënten met bot- en wekedelentumoren op zoek naar een optimale persoonlijke behandelstrategie, vindt prof. dr. Michiel van de Sande. Hij heeft een app ontwikkeld die bij de behandelkeuze ondersteunt. Van de Sande is vanaf 1 mei 2020 benoemd tot Leidse hoogleraar Orthopedie,…
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Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
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Hieratic, Demotic and Greek Studies and Text Editions. Of Making Many Books There Is No End: Festschrift in Honour of Sven P. Vleeming
Dit boek is een Festschrift ter ere van Sven Vleeming met bijdragen van 38 vrienden en collega’s, onder wie bekende specialisten binnen hun respectievelijke vakgebieden.
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Inherited retinal degenerations: clinical characterization on the road to therapy
Promotie
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In search of synergy: novel therapy for metastatic uveal melanoma
Promotie
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Antoni van Leeuwenhoek en LUMC slaan handen ineen voor immuuntherapie
Het eigen afweersysteem van een kankerpatiënt versterken zodat het lichaam zelf beter kankercellen kan vernietigen. Het is de kern van immuuntherapie, de hoopgevendste vooruitgang binnen de behandeling van kanker van de afgelopen jaren. Om deze ontwikkeling verder aan te jagen slaan het Antoni van Leeuwenhoek/Nederlands…
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Therapeutisch vaccin vergroot overlevingskans voor patiënten met baarmoederhalskanker
Patiënten met baarmoederhalskanker hebben een grotere overlevingskans door een therapeutisch HPV-16 vaccin. Een nieuwe studie van het Leidse biotechnologie bedrijf ISA Pharmaceuticals B.V. en het Leids Universitair Medisch Centrum (LUMC) bewijst dat de response van het vaccin versterkt kan worden in…
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Gold nanorod photoluminescence: applications to imaging and temperature sensing
Promotor: M.A.G.J. Orrit
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
Promotie
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Robust Estimation using Aggregated Data for Urban policy making (READ-URBAN)
Read-Urban was een eerste project om te onderzoeken of beleidsaanbevelingen gedaan kunnen worden met behulp van linked dataverzamelingen en data science en om ervaring op te doen met de succesfactoren voor een dergelijk proces.
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Escher and the Droste effect
Artful Mathematics: The Heritage of M. C. Escher
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disease: multimodality imaging for risk stratification and evaluation of therapy
Promotie
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Improving response and reducing toxicity to immune checkpoint blockade therapy in melanoma
Promotie
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The NKG2A / HLA-E axis a novel target for immune checkpoint therapy
Promotie
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Pathogenese en therapie van kanker
Bij kanker groeien lichaamscellen ongecontroleerd. Het gedetailleerd in kaart brengen van hoe dit precies gebeurt maakt het mogelijk om efficiënte therapieën te ontwikkelen. Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken samen aan het vermeerderen van…
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Judith BovéeFaculteit Geneeskunde
j.v.m.g.bovee@lumc.nl | +31 71 526 9111
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Marike KooistraFaculteit der Sociale Wetenschappen
m.j.kooistra@fsw.leidenuniv.nl | +31 71 527 1726
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Targeting for success: Mechanistic insights into microRNA-based gene therapy for Huntington disease
Promotie
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Light therapy for cancer-related fatigue in (non-)Hodgkin Lymphoma Survivors
Promotie
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Text-mining real-world data to evaluate systemic anti-cancer therapy
Promotie
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The Skandapurāṇa Project
Uniting an international consortium of scholars, the Skandapurāṇa Project comprises a team of researchers working in fields across the Humanities. We are creating a critical edition of a foundational work of purāṇic literature and, in doing so, tracing the dynamics of a textual tradition to better understand…