1,359 zoekresultaten voor “high throughput screening and microscopy” in de Publieke website
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High-resolution integral-field spectroscopy of exoplanets
This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.
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Disorder and interactions in high-temperature superconductors
This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.
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Tailored care for children at high risk for problem behaviour
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Painting with starlight : optical techniques for the high-contrast imaging of exoplanets
This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.
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Exploring strange new worlds with high-dispersion spectroscopy
Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Metals in the diffuse gas around high-redshift galaxies
Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)
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Drug Discovery & Safety
In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.
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Prior information and variational Bayes in high dimensional statistical network inference
This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Prying eyes on radio skies: pushing the high-resolution low-frequency frontier with LOFAR
In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.
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Winds in the AGN environment: new perspectives from high-resolution X-ray spectroscopy
Promotor: J.S. Kaastra Co-promotor: E. Constantini
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confronting hydrodynamic simulations with new observations of high-density environments
Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Nano-scale electronic structure of strongly correlated electron systems
In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.
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High throughput glycomics workflows
Promotie
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Néron models in high dimension: nodal curves, Jacobians and tame base change
We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.
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stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
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Statistical learning for complex data to enable precision medicine strategies
Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.
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Radio galaxies at low frequencies: high spatial and spectral resolution studies with LOFAR
Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Probing molecular layers with low-energy electrons
Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…
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Astrophysical plasma modeling of the hot Universe: Advances and challenges in high-resolution X-ray spectroscopy
Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.
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revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Paving the path between low- and high-mass star formation: dynamics probed by Herschel far-infrared spectroscopy
Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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The origins of friction and the growth of graphene, investigated at the atomic scale
Promotor: J.W.M. Frenken
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simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.