19 zoekresultaten voor “streptomyces” in de Publieke website
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom
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the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Moleculaire Biotechnologie naar het Sylvius
De onderzoeksgroep Moleculaire Biotechnologie (MBT) is in de week van 10 december verhuisd naar de vierde verdieping van het Sylvius Laboratorium. De verhuizing van de groep van Professor Gilles van Wezel zorgt ervoor dat alle Microbiologie en Microbiële Biotechnologie onderzoeksgroepen van de Universiteit…
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Slapende antibiotica wakker maken
Bodembacteriën kunnen een schat aan antibiotica maken die nieuw voor ons zijn, stelt Gilles van Wezel. Zijn groep ontwikkelde een methode om die onbekende verbindingen snel te identificeren en te produceren. In Chemistry & Biology laten de onderzoekers zien dat de aanpak werkt.
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Véronique Ongenae
Wiskunde en Natuurwetenschappen
v.m.a.ongenae@biology.leidenuniv.nl | +31 71 527 5075
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Dennis Claessen
Wiskunde en Natuurwetenschappen
d.claessen@biology.leidenuniv.nl | +31 71 527 5052
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Nieuw antibioticum vernoemd naar Leiden
Toenemende resistentie en een gebrek aan nieuwe antibiotica vormen een groot probleem voor de volksgezondheid. Tegen die achtergrond zoekt Gilles van Wezel van het Instituut Biologie Leiden naar nieuwe medicijnen. Samen met toenmalig promovendus Changsheng Wu en collega’s ontdekte hij het bijzondere…
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Joost Willemse
Wiskunde en Natuurwetenschappen
jwillemse@biology.leidenuniv.nl | +31 71 527 4986