969 zoekresultaten voor “high throughput screening and microscopy” in de Publieke website
-
Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
-
Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
-
Pijnstilling zonder high te zijn
Onderzoekers van de Universiteit Leiden onder leiding van Mario van der Stelt (Leids Instituut voor de Chemie) wijzen ‘gouden standaarden’ aan om nieuwe pijnstillers te ontwikkelen die gebaseerd zijn op de medicinale werking van cannabis. Publicatie in Nature Communications.
-
Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
-
Orion's Dragon and Other Stories
Stellar feedback is a crucial ingredient in the evolution of galaxies.
-
model-based quantum machine learning algorithm for prediction and generation of High-Energy Physics data
De huidige en toekomstige quantumcomputers vormen dezelfde uitdaging als de laser in zijn begindagen. In theorie werd voorspeld dat de laser een bron van zeer speciaal, zeer krachtig licht zou zijn. Maar in die tijd waren er geen duidelijke toepassingen voor. Critici van het idee noemden het een probleem…
-
Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
-
Beeldverwerking en bio-informatica
Aan de hand van de karakteristieke aspecten van een beeld kunnen bepaalde computers ons vertellen wat het beeld laat zien. Ze kunnen dit leren op dezelfde manier als jonge kinderen beelden kunnen leren herkennen. Het verder verbeteren van deze technieken opent de weg naar een hele reeks nieuwe toepassingen.…
-
Surveying young stars with Gaia: Orion and the Solar neighbourhood
OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.
-
Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
-
Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
-
Computer vision en beeldverwerking
Aan de hand van de karakteristieke aspecten van een beeld kunnen bepaalde computers ons vertellen wat het beeld laat zien. Ze kunnen dit leren op dezelfde manier als jonge kinderen beelden kunnen leren herkennen. Het verder verbeteren van deze technieken opent de weg naar een hele reeks nieuwe toepassingen.…
-
Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
-
Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
-
Water related adsorbates on stepped platinum surfaces
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
-
Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays
Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
-
Optoplasmonic detection of single particles and molecules in motion
Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.
-
Wim van Anrooij
Faculteit der Geesteswetenschappen
w.van.anrooij@hum.leidenuniv.nl | +31 71 527 2121
-
Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
-
Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
-
Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
-
HEPGAME
HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.
-
European Lead Factory
Overkleeft
-
Meiru Wang
Wiskunde en Natuurwetenschappen
m.wang@cml.leidenuniv.nl | +31 71 527 2727
-
RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
-
Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
-
Barend Mons appointed Chair of European Commission’s High Level Expert Group
Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group
-
High-vrije wiet in trek bij NOS op 3
Het onderzoek van de groep van Mario van der Stelt naar gouden standaarden voor pijnstillende wiet zonder de gebruikelijke high is in een artikel van NOS op 3 verschenen. In een interview legt van der Stelt uit wat dit onderzoek precies voor de wetenschap en de samenleving kan betekenen.
-
Musems, Collections and Society | Yearbook 2020
In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.
-
Rare Earth Supply Chain and Industrial Ecosystem: A Material Flow Assessment of European Union
1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…
-
Microbial communities in Pampa soils; impact of land use changes, soil type and climatic conditions
Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae
-
Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
-
Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
-
investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
-
Orchestration of Distributed LOFAR Workflows
The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.
-
On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
-
Musems, Collections and Society | Yearbook 2021
In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.
-
Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
-
A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
-
Terrorism and Political Violence
Begrijpen van het evoluerende landschap van extremisme in de 21e eeuw.
-
Citizenship, Migration and Global Transformations
Europese burgers worden geconfronteerd met uitdagingen op het gebied van globalisering, migratie, technologische ontwikkelingen en klimaatverandering. Deze uitdagingen vergen het uiterste van onderlinge internationale en intergenerationele solidariteit, wat rechtstreeks betrekking heeft op de grondslagen…
-
Measuring gold molecular gas across cosmic time
Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…
-
Isotopes and the characterization of extrasolar planets
Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.
-
Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
-
Quantum Matter and Optics
Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.
-
Betere screening kan huisarts helpen angststoornissen eerder te herkennen
Slechts een op de vijf minderjarigen met geestelijke gezondheidsproblemen zoals een angststoornis krijgt passende professionele hulp. Huisartsen herkennen vaak niet goed de signalen bij kinderen en jongeren, stelt psycholoog Semiha Aydin. Hoe kan het beter? Promotie op 23 februari.
-
Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
-
Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
-
Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
-
Kristian Rietveld
Wiskunde en Natuurwetenschappen
k.f.d.rietveld@liacs.leidenuniv.nl | +31 71 527 7038