499 zoekresultaten voor “active smit master” in de Publieke website
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Withstanding the cold: energy feedback in simulations of galaxies that include a cold interstellar medium
Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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Many objective optimization and complex network analysis
This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.
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Bestrijdingsmiddelen en Milieu
The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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The heart of oxygenic photosynthesis illuminated
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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“This Path Is Full of Thorns”: Narrative, Subjunctivity, and HIV in Indonesia
In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Vamping the Stage: Female Voices of Asian Modernities
Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).
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Dormancy in stochastic interacting systems
Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Tuning in to the feedback bassline: revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Alumni van de master Jeugdrecht komen naar Leiden voor carrièremiddag en alumni-avond
Op dinsdag 16 april 2019 ontvingen de studievereniging JSV Liberi en de afdeling Jeugdrecht alumni van de master Jeugdrecht tijdens een carrièremiddag en alumni-avond.
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Erik-Jan Zürcher, hoogleraar Turkse talen en culturen, opent de master European Law
Op 8 september kwamen de studenten van de master European Law bijeen in de Lorentzzaal voor de feestelijke opening van hun programma.
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Symposium: The digital reconstruction of the crucifixion of the Lindau master
On 8 July, the symposium 'The digital reconstruction of the crucifixion of the Lindau master (ca. 1425)' will take place at the auditorium of Museum Catharijnecovent, from where it will also be broadcasted online.
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Gastdocent tijdens je master: hoe ervaren de BrainTrain studenten het?
TikTok, WhatsApp, Instagram, YouTube: jongeren besteden veel tijd aan social media. Naast de vele voordelen van dit soort platforms, wordt er ook verkeerde informatie en desinformatie verspreid. Het BrainTrain-team heeft een interactief lesprogramma ontworpen dat hierop inspeelt. Het team van vijf masterstudenten…
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Universiteit Leiden/LUMC schaft cum laude af in de master Geneeskunde
Per 1 september 2024 is er geen predicaat cum laude meer voor de master Geneeskunde. Het College van Bestuur besloot onlangs een ontheffing te verlenen voor de faculteit geneeskunde van Universiteit Leiden/LUMC. Het besluit past in de lijn van andere geneeskunde opleidingen in Nederland.
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Werken bij Wiskunde en Natuurwetenschappen
Werken bij een topfaculteit? Ontdek de vacatures bij Wiskunde en Natuurwetenschappen en solliciteer meteen.
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Star-Forming Galaxies at the Cosmic Dawn
Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens
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Woord van dank en colofon
Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…
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Studenten van de advanced master International Children’s Rights bezoeken Internationaal Strafhof
Op 30 oktober jl. bezochten de studenten van de advanced master International Children’s Rights het Internationaal Strafhof te Den Haag.
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Neem de toekomst in eigen hand met de nieuwe master Governance of Sustainability
Voor studenten die graag een intermediair zijn tussen wetenschappelijke experts, beleidsmakers en politici op het gebied van duurzaamheid, is het masterprogramma Governance of Sustainabiliy wellicht precies wat ze zoeken. De Universiteit Leiden is voornemens deze nieuwe masterstudie in Den Haag te beginnen…
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Studenten van de advanced master International Children’s Rights bezoeken jeugdinrichting De Hunnerberg
Op 25 oktober 2017, bezochten de huidige studenten van de advanced master International Children’s Rights van de Universiteit Leiden justitiële jeugdinrichting ‘De Hunnerberg’ in Nijmegen.
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Gezamenlijke master Industrial Ecology van Universiteit Leiden en TU Delft geaccrediteerd
De gezamenlijke masteropleiding Industrial Ecology van de Universiteit Leiden en TU delft is door NVAO geaccrediteerd als onafhankelijk MSc programma. Industrial Ecology is een opkomende wetenschappelijke discipline die een systematische aanpak naar menselijke problemen voorstaat, waarbij technische…
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Nieuwe master Governance of Sustainability: neem de toekomst in eigen hand
De nieuwe master Governance of Sustainability heeft als doel toekomstige veranderaars op te leiden, die de grote duurzaamheidsuitdagingen van de toekomst vanuit governance-perspectief durven aan te pakken.
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Distant star formation in the faint radio sky
One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Diploma-uitreiking van de master Cyber Security: Een digitaal feestje
Met een reis door Nederland waren de voorbereidingen voor de graduation van de master Cyber Security al weken geleden gestart. De apotheose vond donderdag 11 februari plaats. Een verslag van een digitale diploma-uitreiking.
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Student Master Public Administration Pontus Korgsren in de Volkskrant over de uitbreiding van het geboorteverlof
Op 1 juli is het geboorteverlof voor partners uitgebreid: vijf weken verlof met 70 procent doorbetaling. Veel mensen zijn enthousiast, want de verwachting is dat moeders meer gaan werken. Er is echter ook één probleem. Dit beleid is niet voor iedereen even voordelig.
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Over de faculteit
De faculteit biedt een internationale academische omgeving met 36% van de studenten, promovendi en onderzoekers uit het buitenland.
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Meedoen op afstand in een hybride klas: Interactie met leerlingen met een chronische aandoening
In Nederland zijn ongeveer 35.000 leerlingen met chronische ziekten. Als zij geen onderwijs kunnen volgen in de klas, kan dat mogelijk vanuit huis of een ziekenhuis met hybride onderwijs. De vraag in dit onderzoek is: hoe kan de interactie met de docent en medeleerlingen worden bevorderd?
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Light Weighed: On the Statistics and Systematics of Weak Gravitational Lensing
In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.