1,090 zoekresultaten voor “development disease” in de Publieke website
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4D-Flow MRI of Aortic and Valvular Disease
Promotie
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Developmental cell lineage dynamics in Bicuspid Aortic Valve disease
Promotie
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glycocalyx; a diagnostic and therapeutic target in cardiometabolic diseases
Promotie
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Strategies to Investigate Lipoprotein Metabolism and Combat Cardiometabolic Disease
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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Advanced MRI-markers of cerebral small vessel disease
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Cardiac CT for diagnosis and prognosis of coronary artery disease
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Advanced diagnostic tools in congenital heart disease and pulmonary hypertension
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Consortium DDMoRE lanceert open-access databank
Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.
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Awareness of Students' Skills: an Employability Toolkit for the Humanities (ASSET-H)
Met welke vaardigheden onderscheiden Geesteswetenschappers zich op de arbeidsmarkt? Hoe kunnen we studenten inzicht bieden in hun persoonlijke profiel? Kunnen zij inzicht in hun vaardigheden trainen en monitoren en daarmee hun kansen op de arbeidsmarkt vergroten?
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Tackling chronic respiratory disease in low-resource settings
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Mechanistic Early Phase Clinical Pharmacology Studies with Disease
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Iron-immune interactions in Alzheimer's disease
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Atherosclerotic cardiovascular disease: Interplay between sex, age, and circadian rhythms
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Disentangling the relationship between depression, obesity and cardiometabolic disease
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Carbon4PUR | Turning industrial waste gases (mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
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Lotte Krouwel wint Van den Berg scriptieprijs 2015
Politicologiestudent Lotte Krouwel heeft de Van den Berg Bachelorscriptieprijs 2015 gewonnen met een studie over decentralisatie in ontwikkelingslanden. Naar het oordeel van de jury heeft Krouwel zich onderscheiden door originaliteit, casusselectie en een heldere opbouw van de scriptie.
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Linkages of Sustainability
Exploring linkages between energy and material use and implications for sustainable development.
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Verkenning van islamisering
Kunnen we spreken van één enkel islamitisch discours op gebieden zoals politiek, strijd, economie en duurzame ontwikkeling? En welke interactie bestaat er tussen dit islamitisch denken en 'westers' denken?
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Towards a Sustainable and Circular Metals Economy
In-use stocks of products can be considered as intermediaries between human needs and the physical world.
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Xiaoyang Zhong
Wiskunde en Natuurwetenschappen
x.zhong@cml.leidenuniv.nl | +31 71 527 5148
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Chenguang Gao
Wiskunde en Natuurwetenschappen
c.gao@cml.leidenuniv.nl | +31 71 527 2727
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Joost Visser
Wiskunde en Natuurwetenschappen
j.m.w.visser@liacs.leidenuniv.nl | +31 71 527 2727
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Constraints on large-scale implementation of BioSolarCells, Early stage assessment of environmental value propositions
What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?
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Hersenverbindingen voorspellen impulsiviteit bij pubers
Hersenverbindingen hangen bij pubers samen met impulsiviteit. Bovendien voorspellen ze welke pubers over twee jaar impulsievere keuzes maken, ontdekten Leidse psychologen.
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Lecture Series | Novel approaches to delay ageing and age-related diseases
Lezing, Lezing onderdeel van serie
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Helft jonger, evenveel inzicht
Je zou denken dat 12-jarigen meer weten over drijven en zinken dan 6-jarigen. Uit onderzoek blijkt echter dat de individuele verschillen in inzicht erg groot zijn. Sommige 6-jarigen hebben een beter natuurkundig inzicht dan 12-jarigen.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Kernteam
Het kernteam van het PDC is verantwoordelijk voor onderzoek en ontwikkeling van de LMW-methode en voert het beheer van de LMW trajecten binnen de verschillende deelnemende instellingen.
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Urbanization in Indonesia and Its Impact on Non-communicable Diseases
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Aortic valve disease: multimodality imaging for risk stratification and evaluation of therapy
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in acute myocardial infarction and the assessment of valvular heart disease
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
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