314 zoekresultaten voor “etnische profiling” in de Publieke website
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
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Discrimination and Privacy in the Information Society; Data Mining and Profiling in Large Databases
Laatste technologische ontwikkelingen op het gebied van datamining en profilering.
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Ethical, Legal and Technological Aspects of Data Mining and Group Profiling in Epidemiology
In de afgelopen jaren is het verzamelen en verwerken van tal van gegevens aanzienlijk toegenomen. Met behulp van nieuwe technologieën zoals data mining wordt getracht kennis te halen uit verzamelde gegevens. Vaak wordt gezocht naar profielen die eigenschappen of risico's van bepaalde groepen beschrijven.…
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Peter Rodrigues over etnisch profileren bij de Koninklijke Marechaussee
Gedupeerden zijn een rechtszaak begonnen tegen etnisch profileren door de Koninklijke Marechaussee. Peter Rodrigues, hoogleraar immigratierecht zegt dat etniciteit nooit het belangrijkste criterium mag zijn om iemand staande te houden en verwijst naar een eerdere uitspraak van de Hoge Raad.
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Ymre Schuurmans over etnisch profileren bij de Belastingdienst
Het was al duidelijk dat de Belastingdienst jarenlang met zwarte lijsten werkte met daarop namen van mensen met een, volgens de fiscus, hoog frauderisico. Maar rapporten van onderzoeksbureau PwC maken duidelijk hoe stelselmatig de Belastingdienst discrimineerde bij het bepalen wie er op die lijst th…
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Artikel Maartje van der Woude en Peter Rodrigues over etnisch profileren
Van der Woude en Rodrigues hebben een artikel geschreven in het Nederlands Juristenblad over proactieve politiecontrole naar etnische afkomst en nationaliteit.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Inhibitors and probes targeting endo-glycosidases
The chemical synthesis of inhibitors and probes targeting endo-glycosidases.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
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CONSENT
CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Hermen Overkleeft
Wiskunde en Natuurwetenschappen
h.s.overkleeft@chem.leidenuniv.nl | +31 71 527 5037
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Tsolin Nalbantian
Faculteit der Geesteswetenschappen
t.nalbantian@hum.leidenuniv.nl | +31 71 527 2985
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LinkedIn: profile and network (English)
Loopbaan en solliciteren
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Crimmigratie
Migratie en criminaliteit staan maatschappelijk volop in de schijnwerpers. Binnen het instituut voor Strafrecht en Criminologie heeft onderzoek op dit terrein zich de laatste jaren sterk ontwikkeld. Het begrip Crimmigratie staat daarbij centraal.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Inhibitors and probes targeting PslG
Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…
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Asian Modernities and Traditions
The research profile ‘Asian Modernities and Traditions’ (AMT) aims to raise the strength and visibility of research, teaching and dissemination of Asian studies at Leiden University.
- Aflevering 33: Etniciteit in de middeleeuwen
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Ehsan Jami
Faculteit Governance and Global Affairs
e.jami@fgga.leidenuniv.nl | 070 8009400
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Lights in a sea of darkness: constraining the nature and properties of dark matter using the stellar kinematics in the centres of ultra-faint
Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.
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Emotioneel Werk in de Grensgebieden: Een nieuw perspectief op ethno-raciale profilering
Welke impact hebben discussies over en bewezen beschuldigingen van etnisch profileren op organisaties en de (grens)politieagenten die op operationeel niveau werken? Gedurende een periode van drie jaar (november 2023 – november 2026) zal dit innovatieve transdisciplinaire onderzoeksproject zich richten…
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Bart Custers geeft big data keynote lezing in Japan
Op 23 oktober 2017 geeft mr.dr.ir. Bart Custers, hoofd onderzoek bij eLaw, het centrum voor recht en digitale technologie van de Universiteit Leiden, een keynote lecture over big data en recht op de International Conference on Big Data Research (ICBDR 2017) in Osaka, Japan.