In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Dit jaar staat het Leiden Academic Centre for Drug Research op de 21e plaats op de QS World University Rankings by Subject. Hiermee staat het Leidse instituut op de 1e plaats in Nederland voor het vakgebied Farmacie.

During the course of drug discovery translational steps are made.

Farmacoloog Liesbeth de Lange heeft de Lewis B. Sheiner Lecturer Award van de International Society of Pharmacometrics (ISoP) gewonnen. Als hoogleraar Voorspellende Farmacologie werkt ze onder andere aan een wiskundig model dat medicijnconcentraties in de hersenen kan voorspellen. Ter gelegenheid van…