Het Prisonproject gaat na in hoeverre een gevangenisstraf gevolgen heeft voor onder andere recidive, gezondheid, beroepsloopbanen en intieme relaties van (ex-)gedetineerden.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotie

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

Van systeembiologische modellering een centrale pijler van het onderzoek in de biologie maken.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: S.M. Verduyn Lunel

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Binnen de Life in Custody Study wordt grootschalig onderzoek gedaan naar het leefklimaat in Nederlandse penitentiaire inrichtingen (PI’s).

Op 29 januari 2019 verdedigde Robbert van Eijk proefschrift 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. Het promotieonderzoek is begeleid door promotor prof. dr. H.J. van den Herik.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotores: W. Jiskoot, F. Ossendorp

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotor: Prof.dr. J. Kuiper

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Tax scandals, like the Panama Papers, the Paradise Papers, and the Pandora Papers, have made taxation a major topic of public debate. Learn more about this in the new minor Tax and Society: Building a Sustainable and Fair Tax System.

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: Prof.dr. M. Ubbink

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov