The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

Promotor: P.M. Brakefield

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotor: J.M. Memelink

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotie

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotor: Prof.dr. G.P. van Wezel

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotie

Dit proefschrift behandelt de vraag of er een level playing field is tussen Europese beleggers die beleggen in EU-beleggingsinstellingen en Europese beleggers die beleggen in Amerikaanse beleggingsinstellingen en, als dit niet het geval is, of de Europese wetgever aanvullende regelgeving zou moeten…

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotie

In deze bundel wordt de regulering behandeld van politieke partijen in de post-communistische EU-landen, met name Bulgarije, Croatië, Tsjechië, Estland, Hongarije, Letland, Litouwen, Polen, Slowakije, Slovenië en Roemenië.

Op 10 oktober 2019 verdedigde Laure d'Hondt haar proefschrift 'Addressing Industrial Pollution in Indonesia. The Nexus between Regulation and Redress seeking'. Het promotieonderzoek is begeleid door promotor prof.dr. A.W. Bedner.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Matthias Haentjens, Jouke Tegelaar en Dorine Verheij schreven het hoofdstuk Financial Market Regulation and Supervision, dat recentelijk is gepubliceerd in het belangwekkende handboek The Law of the European Union (voorheen Kapteyn & VerLoren van Themaat).

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

De onderzoeksgroep ‘Diplomacy and Global Affairs’ houdt zich bezig met onderwerpen zoals de veranderende globale machtsverhoudingen, (internationale) diplomatiek, het beheersen en oplossen van conflicten, de inspanningen van spelers zoals internationale, multilaterale, regionale en non-gouvernementele…

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Promotie

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Historische migratiestudies hebben zich lange tijd voornamelijk gericht op de Europese en Atlantische wereld. In dit programmatische langetermijnproject willen we het perspectief verbreden naar de volledige migratie-ervaring van de niet-westerse wereld.

Centraal in de Liberal Arts & Sciences opleiding van LUC staan Global Challenges: grote uitdagingen waar de wereld en de mensheid voor staat, zoals duurzaamheid, vrede & rechtvaardigheid, welvaart en diversiteit.

De minor Global Affairs is gebouwd op twee pijlers van Internationale Betrekkingen: Internationale Veiligheid en Internationale Politieke Economie. Het doel van deze minor is om studenten de instrumenten en kennis te geven om de belangrijkste mondiale trends en uitdagingen te begrijpen.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Op 12 september 2019 verdedigde Michiel Rhoen zijn proefschrift 'Big Data, Big Risks, Big Power Shifts: Evaluating the General Data Protection Regulation as an instrument of risk control and power redistribution in the context of big data'. Het promotieonderzoek is begeleid door promotoren prof.dr.mr.…

In the spring of 2025, Studium Generale will host several Global Challenges lectures at Leiden University College The Hague. We begin on December 10, 2024, International Human Rights Day, with a panel discussion about children's rights in conflict zones, focusing on the right to education during and…

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.