Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotor: Prof.dr. M.L. van Hecke

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Promotor: J.W.M. Frenken

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Control of infectious diseases poses continuous challenges for human health.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Make use of this time to improve your language skills by signing up for custom-made online language classes.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Promotor: Prof.dr.ir. E. Deprettere

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

De Academy of Creative and Performing Arts is een samenwerkingsverband tussen de Leidse universiteit en de Hogeschool der Kunsten Den Haag'. (Deeltijd)studenten van de Leidse universiteit kunnen hier theoretisch en praktisch kunstvakonderwijs volgen, waarvan de studiepunten meetellen voor hun bachelor-…

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

This interdisciplinary study focuses on (trans)national ethnic and popular networks, combining historical-ethnographic and computational methods to understand the ‘workings’ of networked conflict interfering in the increasingly violent conflict in the Sahel (Africa) and beyond. The project focuses on…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…