Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Lezing

In de oorlog tussen Rusland en Oekraïne heeft Japan partij gekozen voor Oekraïne. In het radioprogramma ‘Met het oog op morgen’ legt Anoma van der Veere uit waarom dit opmerkelijk is.

Op dinsdag 2 mei 2017 is de H.A.Brasz scriptieprijs van de Vereniging voor Bestuurskunde uitgereikt aan Joanne Langkamp , als masterstudent afgestudeerd aan de Universiteit Leiden bij Joris van der Voet en Sandra Groeneveld. Joris van der Voet nam de prijs voor haar in ontvangst.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

De coronacrisis is de ultieme test voor bestuurders. Hoe houden nationale politieke leiders zich staande in hectische, dynamische tijden? Martin Lodge (London School of Economics and Political Science) en (Arjen Boin (Instituut Politieke Wetenschap Universiteit Leiden) bekijken de ervaringen opgedaan…

Nederlandse kamerleden worden vooral gemotiveerd door hun directe werkomgeving: de parlementaire en partij-instituties en de daar geldende normen.

Wist je dat je na succesvolle afronding van de minor Chinese Economy and Society een aansluitende masteropleiding kunt volgen? Lees hier meer over de masteropleiding Asian Studies (MA).

Er is nogal wat variatie in de mate waarin parlementaire stemmingen verlopen volgens de scheidslijn regering-oppositie. Hoe zijn deze verschillen te verklaren? Party Politics artikel van Tom Louwerse et al.

De master History van de Universiteit Leiden heeft een sterk internationaal karakter en focust op Europese- en niet-Europese geschiedenis vanuit een globale context.

De master Asian Studies van de Universiteit Leiden is een hoogwaardige opleiding bij één van de meest vooraanstaande centra voor Aziëstudies in Europa.

Op vrijdag 8 november 2019, hield Ron Keller, voormalig ambassadeur van Nederland in China, Turkije, Oekraïne en Rusland, een gastcollege bij het Institute of Security and Global Affairs.

NWO Geesteswetenschappen heeft aan twaalf onderzoeksteams financiering toegekend vanuit de Vrije competitie geesteswetenschappen. Via dit instrument is financiering beschikbaar voor de beste geesteswetenschappelijke onderzoeksvoorstellen, zonder thematische randvoorwaarden.

Kunst en cultuur, Artist Lecture & Workshop

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Promotor: G.J.B. van Ommen

Joris Larik werd afgelopen vrijdag door BBC World Service radio geïnterviewd over de status van de Brexit - onderhandelingen, het probleem met de Ierse grens en de doorlopende Nederlandse voorbereidingen.

Op 29 februari verscheen er een column van Maaike Warnaar in de Volkskrant over de Iraanse verkiezingen.

Universe in a Box is erkend voor zijn educatieve waarde, door het Europese netwerk van Wetenschapseducatie (Scientix).

Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.

Het moet vanzelfsprekend worden om te investeren in kunst en cultuur. Dat stelde staatssecretaris Gunay Uslu vrijdagavond in de Huizingalezing. ‘Laten we volmondig erkennen dat we cultuur nodig hebben.’

Abeer Abazeed, promovendus aan het Institute of Security and Global Affairs, verdedigt op woensdag 21 april haar proefschrift. Vier vragen over haar promotie-onderzoek 'Is it One Nile? Civic engagement and hydropolitics in the Eastern Nile Basin’

In een paar jaar tijd is het beleid van de Chinese regering ten opzichte van de Oeigoeren sterk verslechterd. Van controle en marginalisering ging het naar een schending van mensenrechten. Promovenda Elke Spiessens zat er met haar onderzoek middenin. ‘De vezels van de gemeenschap worden volledig weg…

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.