In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

The global agri-food system plays a critical role in food security and environmental issues.

Op 14 november 2019 verdedigde Luis Fiallos Pazmino zijn proefschrift 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. E.C.P.D.C. De Brabandere.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: S.M. Verduyn Lunel

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. E. Smets, M. Stech

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Instituut voor Publiekrecht omvat het publiekrecht, met uitzondering van het strafrecht en inclusief het sociaal recht.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Creating information portals for support of European environmental policy.

Op 19 december 2019 verdedigde Reza Eftekhar zijn proefschrift 'The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival of the Localisation Theory'. Het promotieonderzoek is begeleid door promotor prof.dr. E.…

Op 28 februari 2019 verdedigde Kabir Duggal zijn proefschrift 'Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences'. Het promotieonderzoek is begeleid door promotor prof. dr. E. De Brabandere.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Heb je nog vragen over de opleiding Franse taal en cultuur? Neem dan gerust contact met ons op!

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Promotor: F.J. van Lunteren, E. Jorin

Heb je nog vragen over de opleiding Italiaanse taal en cultuur? Neem dan gerust contact met ons op!

Studenten die niet direct toelaatbaar zijn tot de Educatieve master Frans komen mogelijk in aanmerking voor een pre-masterprogramma.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotores: T.H. Oosterkamp, N. de Jonge

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Op dinsdag 27 juni 2017 verdedigde Camiel E.J.M. Hanegraaf zijn proefschrift “Artikel 2:11 BW: doorgeefluik van bestuurdersaansprakelijkheid. Hoe diep kan een bestuurder vallen?”. Promotor is prof. mr. S.M. Bartman.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.