2,097 zoekresultaten voor “rondom were in room environmental” in de Publieke website
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Shaping the European External Action Service and its post-Lisbon crisis management structures
This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Learning from nature: using plant-soil feedback principles to improve growth and health of a horticultural crop
Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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The Proliferation of Dissenting Opinions in International Law
Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Ecology of the Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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Compressed Σ-Protocol Theory
In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.
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Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Software developments in automated structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
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spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
- Summer School: "Manuscript Studies: Codicology and Digital Techniques" (5 ECTS)
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Contact
De Faculteit of Governance and Global Affairs is actief op verschillende social media, volg deze accounts om op de hoogte te blijven van alles op en rondom de Universiteit.
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In de afgelopen jaren is er een grotere manifestatie te zien van extreemrechtse denkbeelden en incidenten in West-Europa.
In de cursus ‘ontwikkelingen rondom rechts-extremisme ’ wordt een overzicht gegeven van de ontwikkelingen rondom rechts-extremisme in de afgelopen decennia en wordt ingegaan op de (gewelds)dreiging die hiervan uitgaat.
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Veiligheid
De opleidingen op het gebied van Veiligheid behandelen onderwerpen als extremisme, ondermijning, recht, terrorisme en meer. Bekijk alle veiligheidsopleidingen van het CPL.
- MS Cognitietour: Meppel
- MS Cognitietour: Horst
- MS Cognitietour: Zuid-Holland West
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Schrijf je in voor de nieuwsbrief Veiligheid, Diversiteit en Inclusie of Public Affairs
Schrijf je in voor de nieuwsbrief en blijf op de hoogte van het laatste nieuws binnen jouw vak- of interessegebied. Zo weet jij als eerste welke cursussen er worden aangeboden in de komende periode, lees en luister je relevante interviews met (academische) professionals en weet je welke wetenschappelijke…
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Phanta Rhei: recht en duurzaamheid
In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.
- MS Cognitietour: Enschede
- MS Cognitietour: Almere
- The global challenge of the environmental impact of nanomaterials and how to develop better (nano)technologies (The Hague)
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Rhythms of resilience: Individual differences in genetic and environmental effects on brain development
Promotie
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bundel De constitutionele conventie: kwal op het strand of baken in zee?
Onlangs verscheen onder redactie van Luc Verhey en Gert Jan Geertjes een bundel over de constitutionele conventie bij Boom juridische uitgevers.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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International House
Kaiserstraat 13, Leiden
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Aangesloten onderzoekers
Het GTGC-netwerk omvat momenteel meer dan 160 onderzoekers verspreid over 6 faculteiten van de Universiteit Leiden. We stimuleren met name thematische interfacultaire samenwerkingen rondom een breed scala aan globale transformaties en bestuurlijke uitdagingen.
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ECMO Basiscursus
Ontdek de ECMO Basiscursus van Boerhaave Nascholing en leer over alle theoretische en praktische aspecten van ECMO. Lees hier meer!
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POBOT Advanced Training: kind
Ontdek de cursus POBOT Advanced Training KIND van Boerhaave Nascholing en leer over botulinetoxine behandelingen bij kinderen. Lees hier meer!
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Van Krevelenwebinar XVIII: Eetstoornissen
Ontdek de Van krevelingenwebinar van van Boerhaave Nascholing en leer tijdens deze editie meer over eetstoornissen. Lees hier meer!