10,000 zoekresultaten voor “leiden” in de Publieke website
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Data Centres for Natural Recources and Products
Creating information portals for support of European environmental policy.
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Dubbelspoor. De postuum verschenen herinneringen van professor Cees Fasseur (1938 - 2016).
Dubbelspoor. De postuum verschenen herinneringen van professor Cees Fasseur (1938 - 2016).
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Good practices in the Caribbean: rechtshandhaving en rechtstaat
De centrale vraag is wat Nederland kan leren van de wijze waarop deze landen de rechtshandhaving en de rechtstaat in hun overzeese gebieden hebben ingericht.
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences
Op 28 februari 2019 verdedigde Kabir Duggal zijn proefschrift 'Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences'. Het promotieonderzoek is begeleid door promotor prof. dr. E. De Brabandere.
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Profinite groups with a rational probabilistic zeta function
Promotores: H.W. Lenstra, A. Lucchini
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Van woord tot akkoord. Een analyse van de partijkeuzes in CPB-doorrekeningen van verkiezingsprogramma's en regeerakkoorden, 1986-2017
This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.
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Fysieke gezondheid
Hoe blijven we toch fit nu we meer thuiswerken?
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Academie der Kunsten (ACPA)
Academy of Creative and Performing Arts (ACPA) verzorgt artistiek onderzoek en onderwijs in de kunsten. ACPA is een onderzoeksinstituut van de Faculteit der Geesteswetenschappen en onderdeel van een samenwerkingsverband tussen de Hogeschool der Kunsten Den Haag en de Universiteit Leiden.
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Domestic Courts in Investor-State Arbitration: Partners, Suspects, Competitors
Op 27 juni 2019 verdedigde Vid Prislan zijn proefschrift 'Domestic Courts in Investor-State Arbitration: Partners, Suspects, Competitors'. Het promotieonderzoek is begeleid door promotor prof. dr. N.J. Schrijver.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
- Diversiteit in onderzoek en onderwijs
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Sound Investigation: Effects of noise on marine animals across trophic levels
Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…
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Rol van daders, slachtoffers en omstanders bij geweldsincidenten
Sommige ernstige geweldsincidenten eindigen met dodelijke afloop, andere niet. Vooral vuurwapengebruik door de dader, de aan- of afwezigheid van omstanders en het gedrag van het slachtoffer blijken cruciaal voor deze uitkomst.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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AI-MAPS
AI MAPS richt zich op drie thema's om de belangrijkste uitdagingen op het gebied van veiligheid aan te pakken, en benadert deze door de lens van vrijheid en sociaal welzijn.
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ProParte Tuinclub
De Tuinclub is een subvereniging van ProParte.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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Quality-driven multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Inverse Jacobian and related topics for certain superelliptic curves
To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
- Activiteiten
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Leer te durven!
Het ‘Leer te Durven!’ programma is een preventieve training voor kinderen met lichte angstklachten (Simon & Bögels, 2014). Het programma is speciaal ontwikkeld voor kinderen tussen de 8 en 12 jaar die zich angstig voelen of angstig gedragen, situaties vermijden, bang zijn om dingen fout te doen, schrikachtig…
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Wereldgeschiedenis van Nederland
In deze vuistdikke bundel vertellen meer dan honderd Nederlandse onderzoekers het wereldwijde verhaal van de Nederlandse geschiedenis
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A time-space translation mechanism for patterning the vertebrate anteroposterior axis
My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.
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On the Emergence of the Energy Transition
The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.
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Hydrodynamics and the quantum butterfly effect in Black Holes and large N quantum field theories
Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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An Algebra for Interaction of Cyber-Physical Components
Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Supporting medical teachers' learning: redesigning a program using characteristics of effective instructional development
Docenten in het hoger onderwijs zijn experts in wát zij doceren, maar niet noodzakelijk in hóe zij dit zouden moeten doen. Dit komt omdat zij vaak weinig tot geen training hebben gehad in het lesgeven. Daarnaast zijn zij over het algemeen meer georiënteerd op hun eigen vakgebied dan op hun rol als docent.…
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Strafrecht en publieke opinie
Op 3 november 2021 verdedigde Lucas Noyon het proefschrift 'Strafrecht en publieke opinie'. Het promotieonderzoek is begeleid door prof.mr. J.H. Crijns en prof.dr. J.W. de Keijser.