In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Prof.dr. J. Memelink

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

During the course of drug discovery translational steps are made.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

Remus Dame

Enforcement of group cooperation fails because of discriminatory punishment, according to research by Welmer Molenmaker and colleagues. When group members have different backgrounds, punishment turns into a double-edged sword: no longer used just to prevent group exploitation, but also to break the…

De centrale vraag is wat Nederland kan leren van de wijze waarop deze landen de rechtshandhaving en de rechtstaat in hun overzeese gebieden hebben ingericht.

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Met het SAPPAO-project willen we de voorspelling van geplande vluchten nauwkeuriger en betrouwbaarder maken. De volledige naam van het project is ‘A Systems Approach towards Data Mining and Prediction in Airlines Operations’.

Promotie

Promotie

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Sustainable energy from wind and solar is most readily available near the sea.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Heb je een vraag over het studentenleven in Leiden, studeren aan de Universiteit Leiden of ben je op zoek naar informatie over de opleiding Archeologie of de specialisatie World Archaeology? Kom direct in contact met één van onze studenten!

VALUE (Videogames and Archaeology at Leiden UnivErsity) publiceert een nummer over het snijvlak tussen archeologie, erfgoed en videospellen. In dit nummer komen wetenschappers en game designers samen om te laten zien hoe deze beroepsgroepen samen kunnen werken.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: Prof.dr. J.W.M. Frenken

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. C.U. Keller

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…