The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. C.U. Keller

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Forgotten Lineages explores the paths through which generations of formally enslaved and their descendants gradually forgot their past of enslavement under Dutch and British imperial rule and became local subjects in Sri Lanka and South Africa. It explores why and how forgetting rather than memory became…

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotor: C.J. ten Cate

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: Prof.dr. J. Kuiper

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: G.P. van Wezel

Promotor: J. Kuiper

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: J. Zaanen

Including modelling as part of software development appears to have various benefits.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotores: T.H. Oosterkamp, N. de Jonge

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: J.M. Memelink

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Moritz Jesse, Universitair Hoofddocent Europees Recht aan het Europa Instituut, heeft zijn boek “The Civic Citizens of Europe: The Legal Potential for Immigrant Integration in the EU, Belgium, Germany, and the United Kingdom

Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

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Like a mixture of oil and water, lipid membranes separate into two liquid phases.

De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.