Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

A new publication on changes in the relationship between news and their public in Chile

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: M.A.G.J. Orrit

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: P.D. Grünwald

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Control of infectious diseases poses continuous challenges for human health.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotores: W. Jiskoot, F. Ossendorp

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Promotor: Prof.dr. G.R. de Snoo

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Participants in this course will learn to support student teachers and new colleagues in their professional development as teachers, with particular emphasis on the context of bilingual or international education, as in the ICLON World Teachers Programme (WTP).

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

How did colonial law work to turn people into property? This project argues that colonial ideas about households and domestic authority were critical to legal processes of enslavement in the early modern Dutch empire. Using colonial court records from Dutch Brazil, Suriname, and the Moluccas, the project…

Kunst en vrije tijd, Kunst en vrije tijd

Leidse wetenschappers en studenten bloggen en podcasten over onderzoek en onderwijs.

Dr. Marcia Goddard ontdekte dat de hersenen van 2 groepen jongens met symptomen van autisme verschillen. Dit is nooit eerder aangetoond. ‘Blijkbaar is er binnen het autisme spectrum op belangrijke punten variatie in de hersenmechanismen die tot bepaald gedrag leiden.’ Dit pleit voor behandeling op maat…

De Nederlandse Vereniging voor Autisme (NVA) heeft emeritus-hoogleraar Orthopedagogiek Ina van Berckelaer-Onnes in de Eregalerij van de Canon Sociaal Werk opgenomen. Van Berckelaer-Onnes heeft veel betekend voor de Nederlandse autismegemeenschap.

Loopbaan en solliciteren

Leidse alumnus Peter Buis en promovendus Mink van IJzendoorn bestudeerden op verzoek van Huis van Hilde het levenswerk van Herman Zomerdijk. Zomerdijk (overleden 15 maart 2014) was een Bakkumse bollenkweker en een gedreven detectorzoeker. Met zijn metaaldetector zocht hij decennialang naar munten en…