The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

From October 17 to October 20, the international conference "Patristic Sermons in the Middle Ages: Collections, Mediators and the Practice of Compiling" will take place at the Dutch Royal Institute in Rome. Research Master students can obtain 2 ECTS by participating in this conference an an additional…

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

During the course of drug discovery translational steps are made.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotor: Prof.dr. J. Kuiper

Promotor: C.J. ten Cate

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Promotor: G.P. van Wezel

Promotor: J. Kuiper

Promotor: J. Zaanen

Promotor: Prof.dr. C.U. Keller

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Oekraïne staat op het punt kandidaat-lidstaat van de EU te worden, maar problemen met corruptie en de rechtsstaat kunnen de Europese integratieaspiraties elk moment dwarsbomen: zowel nu als op de lange weg naar het lidmaatschap.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Moritz Jesse, Universitair Hoofddocent Europees Recht aan het Europa Instituut, heeft zijn boek “The Civic Citizens of Europe: The Legal Potential for Immigrant Integration in the EU, Belgium, Germany, and the United Kingdom

The Leiden University Centre for the Arts in Society (LUCAS) invites applications for a postdoctoral Researcher (0.8 fte for 3 years) in the ERC Starting Grant project ‘Pages of Prayer: The Ecosystem of Vernacular Prayer Books in the Late Medieval Low Countries, c. 1380-1550’ (PRAYER). Candidates are…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Enforcement of group cooperation fails because of discriminatory punishment, according to research by Welmer Molenmaker and colleagues. When group members have different backgrounds, punishment turns into a double-edged sword: no longer used just to prevent group exploitation, but also to break the…

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Voor het eerst is onderzocht hoe de gezondheid van gedetineerden voorafgaand aan de detentie verschilt van niet-gedetineerden en in welke mate de gezondheidsproblemen veranderen over de tijd: van vóór naar ná de detentieperiode.

De specialisatie Politics, Culture and National Identities, 1789 to the Present (research) van de Universiteit Leiden brengt je in de voorhoede van de nieuwe benadering van de manier waarop in Europa politiek en identiteit worden opgevat.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.