LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: Prof.dr. J.W.M. Frenken

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Per 1 mei is Casper de Jonge benoemd tot hoogleraar Griekse Taal- en Letterkunde. ‘De Griekse literatuur komt niet alleen uit Athene: ook auteurs uit Egypte, Syrië en Klein-Azië schreven in het Grieks.’

Een samenwerking tussen het Instituut voor Strafrecht & Criminologie van de Universiteit Leiden en de hoogleraren strafrecht Marc Thommen en Sarah Summers van de Universität Zürich heeft voor een tweede maal geleid tot een interessant en leerzaam seminar voor Zwitserse en Leidse studenten.

Promotor: Prof.dr. C.U. Keller

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotor: C.J. ten Cate

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: Prof.dr. J. Kuiper

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: G.P. van Wezel

Promotor: J. Kuiper

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: J. Zaanen

Including modelling as part of software development appears to have various benefits.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotores: T.H. Oosterkamp, N. de Jonge

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

On the occasion of the appearance of the monograph "Varieties of the Self.Peter Abelard and the Mental Architecture of the Paraclete" written by Babette Hellemans and published at Brill in 2023, a workshop will be organized concerning rules of observance as ‘texts of life’ in ascetic communities. The…

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea