Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Development of GHG calculator for bio-electricity and heat.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

The applications of studying the early development of insects range from agriculture to material science.

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Promotores: W. Jiskoot, F. Ossendorp

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotor: Prof.dr. G.R. de Snoo

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

De podcastserie De Verbranders van promovendi Neske Baerwaldt (FdR/VVI) en Wiebe Ruijtenberg (FSW/CAOS) is vanaf nu te beluisteren op Soundcloud, Spotify, en Apple Podcasts. De serie wordt dit jaar in verschillende vakken als lesmateriaal ingezet. Het project wordt mede mogelijk gemaakt door het Elise…

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Migranten drukken veel minder zwaar op de begroting van Europese landen dan vaak wordt gedacht. In veel gevallen is hun bijdrage positiever dan die van de autochtone bevolking. In een aantal landen dragen migranten zelfs netto bij aan de overheidsfinanciën. Dat blijkt uit onderzoek van economen van…

Door globalisering, migratie en technologische vooruitgang moeten politici ingewikkelde keuzes maken op het gebied van sociale zekerheid en arbeidsmarktbeleid. Bijzonder hoogleraar Olaf van Vliet vertelt erover in zijn oratie op 7 juni.

Migranten drukken veel minder zwaar op de begroting van Europese landen dan vaak wordt gedacht. In veel gevallen is hun bijdrage positiever dan die van de autochtone bevolking. In een aantal landen dragen migranten zelfs netto bij aan de overheidsfinanciën. Dat blijkt uit onderzoek van economen van…

Woensdagavond 11 augustus was Patrick van Berlo te gast in het radioprogramma Met ’t Oog op Morgen van de NOS (NPO Radio 1) om te spreken over uitgelekte incidentrapporten uit het Australisch-Nauruaans detentiecentrum op Nauru. Over dat onderwerp werd hij eveneens geïnterviewd in de Volkskrant van 12…

Asielzoekers geven regelmatig een andere leeftijd op in verschillende EU-landen. Waarom doen ze dat? En hoe weet je hoe oud ze écht zijn? Immigratiedeskundige Mark Klaassen vertelt erover in onze podcast Enkeltje Wetenschap.

Koen Caminada licht in de Volkskrant onderzoek over de stabiele inkomensverhoudingen in Nederland toe.

Promotie

Sophie Feyder is een van de winnaars van de Praemium Erasmianum dissertatieprijs. Op 3 mei 2016 promoveerde zij cum laude op het proefschrift ‘Portraits of Resilience. Writing a Socio-Cultural History of a Black South African Location with the Ngilima Photographic Collection. Benoni, 1950s-1960s’.

Twee jaar na het verjagen van de vorige president houdt Sri Lanka presidentsverkiezingen. Nira Wickramasinghe, professor Modern South Asian Studies aan de Universiteit Leiden, geeft haar visie in een NRC-artikel.

The project

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…