Ons bacheloronderwijs sluit nog niet altijd goed aan bij het niveau van onze master-opleidingen. Dit team zal uitwerken hoe deze aansluiting beter kan warden en hoe het afstudeertraject hierin een rol kan spelen.

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Cardiovascular disease is the leading cause of death worldwide.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

A neuro-ecological perspective on adolescent prosocial development

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Cardiovascular syndromes are the major cause of death in Western societies.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Promotor: Prof.dr. G.P. van Wezel

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: J. Aarts

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

De programmagroep Leer- en Gedragsproblemen in het Onderwijs doet onderzoek naar stagnaties die kunnen optreden in de cognitieve ontwikkeling.

In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.

A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Studievoorlichting

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Sinds de start van de Green Office zijn er verschillende projecten gestart om de bewustwording onder medewerkers & studenten te vergroten en de universiteit te verduurzamen. Lees hier alles over onze huidige projecten.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

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Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Met het afronden van je bachelor zet je een belangrijke stap. Maar daarmee is je academische vorming nog niet helemaal ‘af’. Veel opleidingen en banen vragen om meer. Daarom stimuleert de Universiteit Leiden je om na je bacheloropleiding door te gaan met de masteropleiding. Jouw Leidse bachelordiploma…

Promotor: G.P. van Wezel, Co-promotor: D. Claessen