It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Promotor: J.S. Kaastra Co-promotor: E. Constantini

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Promotie

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Promotor: Prof.dr. H.J.A. Rottgering

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotores: H.A. Udo De Haes, P.M. Brakefield

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotor: P.D. Grünwald

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.