Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Het aantal leeuwen in Afrika neemt sterk af. Over twintig jaar zijn de populaties van de meeste soorten zelfs gehalveerd. Waarom gaat het zo slecht met de leeuw? - Radio Interview met Hans de Iongh van CML bij De Kennis van Nu - NPOwetenschap.nl

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

This dissertation presents new cryptographic protocols, which can be divided into two families.

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

What categories exist in the languages of pastoralists? Do these semantic concepts reflect universal or languagespecific tendencies? What (environment? culture?) governs the similarities (or the differences) attested crosslinguistically in cattle colour systems?

Universiteit Leiden gaat haar samenwerking met kennisinstellingen in Afrika verder verdiepen. Tijdens een reis naar Ghana is met diverse kennisinstellingen uit Afrika doorgepraat over intensievere samenwerking.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Universiteit Leiden en 4 andere universiteiten gaan 51 promovendi aanstellen om voor en met het Afrikaanse continent oplossingsgericht onderzoek te doen.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

African oral literatures, new media and technologies: challenges for research and documentation

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Noord-Koreaanse arbeiders ontwierpen en bouwden in zuidelijk Afrika talloze monumenten, musea en andere gebouwen, laat geschiedenisstudent Tycho van der Hoog zien in zijn masterscriptie. Het zijn belangrijke inkomsten voor een land dat op het politieke wereldtoneel behoorlijk geïsoleerd is geraakt.

This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.

What Determines Perceptions of Bias toward the International Criminal Court? Evidence from Kenya. In dit artikel, gepubliceerd in op de website SAGE Journals in het Journal of Conflict Resolution, onderzoeken de auteurs Geoff Dancy, Yvonne Marie Dutton, Tessa Alleblas, Eamon Aloyo de houding ten opzichte…

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

Sobral

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Dit artikel gaat in op de onderzoekskloof door te onderzoeken hoe deze instanties hun personeel zo kunnen inzetten dat ze maximale prestaties leveren met het personeel dat ze hebben.

Om de klimaatcrisis het hoofd te bieden, kan een bepaalde nederigheid van de mens ten aanzien van de natuur van groot belang zijn. Tegelijkertijd kan nederigheid ook politieke overheersing in de hand werken. Hoe kunnen mensen zich op een bescheidener manier tot de natuur verhouden zonder hun vrijheid…

Onder welke omstandigheden beperken paramilitaire groepen hun gebruik van politiek geweld? Dit artikel onderzoekt het gebruik hiervan door de PIRA.

Ramesh Ganohariti onderzoekt de juridische identiteit in drie post-Sovjet aspirant-lidstaten en schetst in dit artikel vier veelvoorkomende scenario's.

Jaroslaw Kantorowicz and Rok Spruk onderzoeken de bijdrage van institutionele hervormingen aan economische groei.