Promotor: Prof.dr. J.W.M. Frenken

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

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De Nobelprijs voor Scheikunde 2017 is uitgereikt aan Jacques Dubochet, Richard Henderson en Joachim Frank, voor hun ontwikkeling van de cryo-elektronenmicroscopie. Met deze techniek kunnen biomoleculen in 3D in beeld gebracht worden, legt hoogleraar Ultrastructuurbiologie Ariane Briegel uit.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotor: J.W.M. Frenken

'Het Nederlands Centrum voor Elektronen Nanoscopie (NeCEN) is een mooi voorbeeld van een faciliteit die op nationale schaal toegang biedt tot de laatste ontwikkelen op het gebied van cryo-elektronen microscopie', dat schrijft Sriram Subramaniam, een vooraanstaand leider in deze tak van sport, in het…

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Natuurkundige Daniël Geelen ontwikkelde tijdens zijn promotie een nieuwe microscoop die laag-energetische elektronen gebruikt. Zulke elektronen zijn minder schadelijk voor biologische en organische materialen. Geelen promoveert op 31 mei.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

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The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: Prof.dr. C.W.J. Beenakker

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How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

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In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

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Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Intensive care-afdelingen overal ter wereld kunnen hun doseringen voor morfine bij baby’s en peuters gaan aanpassen. Met een nieuwe methode ontdekte farmacologe Elke Krekels dat gebruikelijke doseringen bij pasgeborenen te hoog zijn, en bij peuters juist te laag. Promotie 10 oktober.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

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De Europese Unie heeft tien miljoen euro geïnvesteerd in het zogeheten iNEXT-Discovery consortium. Het consortium wil innovatief structureel biologisch onderzoek beter toegankelijk maken voor Europese onderzoekers. Ook het Netherlands Centre for Electron Nanoscopy (NeCEN) maakt deel uit van iNEXT-Disovery,…

De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, waaronder Leids natuurkundige Michel Orrit.

Promotor: Prof.dr. L.J. Slikkerveer

Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

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