In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Promovendus en onderzoeksjournalist Sebastiaan Grosscurt heeft in mei een Tegel gewonnen. In de categorie data wonnen Grosscurt en zijn collega’s de prestigieuze journalistieke prijs. ‘Ecologisch onderzoek en journalistiek zijn voor mij twee manieren om hetzelfde te bereiken.’

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: M.A.G.J. Orrit

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Veel mensen denken dat zware metalen giftig zijn en mens en natuur altijd schade aanbrengen. Dat beeld moet genuanceerd worden, vindt hoogleraar Sylvestre Bonnet.

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Kunst en vrije tijd, Kunst en vrije tijd

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Promotie

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Promotor: Prof.dr. H.V.J. Linnartz

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Chemotherapie die niet schadelijk is voor het lichaam, maar wel effectief optreedt tegen kankercellen: dat is het doel van de onderzoeksgroep van chemicus Sylvestre Bonnet. Tijdens zijn promotieonderzoek bracht chemicus Xuequan Zhou dat doel een stukje dichterbij. Hij ontwikkelde moleculen die, eenmaal…

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Promotor: H.J.M. de Groot

Development of indicators to assess decoupling of economic development and environmental pressure in the EU-25 and AC-3 countries.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

Promotor: R.D. Gill, F. Taroni

LiDAR is een relatief nieuwe meettechniek waarmee het Actueel Hoogtebestand Nederland het hele land zeer nauwkeurig mee heeft ingemeten. Het grote voordeel van deze manier van meten is dat vegetatie geen belemmering vormt. Hierdoor kunnen ook gebieden waar vegetatie de zichtbaarheid van de ondergrond…

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.