236 zoekresultaten voor “lipid chair leon” in de Publieke website
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Met grafeen door het lichaam reizen
Het is onderzoekers voor het eerst gelukt grafeen op een stabiele laag vetten, ofwel lipiden, te plaatsen. Omringd door een beschermende laag van lipiden zou grafeen in het lichaam als een veelzijdige sensor kunnen dienen. De resultaten zijn de eerste stap naar zo’n omhulsel en zijn op 28 september…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Een vette oplossing voor eczeem
Farmacoloog Walter Boiten ontwikkelde een nieuwe methode om de hoeveelheid vetten in iemands huid te kunnen bepalen. Met de methode testte hij de effecten van een nieuwe crème die hij ontwikkelde voor eczeempatiënten. De eerste resultaten zijn veelbelovend. Boiten promoveert op 15 januari.
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Physics implications of shape on biological function
Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Photocatalytic redox reactions at the surface of liposomes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Cleveringa-boeken geschonken aan de Universiteit Leiden
Twee Cleveringa-boeken uit de juridische bibliotheek van Theo ten Kate zijn 24 november geschonken aan de Universiteit Leiden door diens kleinzoon Sebastiaan ten Kate. Het zijn proefschriften van W. Hugenholtz en J.G.L. Röder, beiden promovendi van Rudolph Pabus Cleveringa. Ten Kate: ‘Bij de universiteit…
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Full Professor 'Clinical Developmental Psychology'
Full Professor 'Clinical Developmental Psychology’The full professor should be dedicated to the understanding of child and adolescent mental health, in particular at the interface of Developmental Psychopathology and Clinical Child and Adolescent Psychology. What you will doThe chair position is part…
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The Right to Travel by Air of Persons with Disabilities
Op donderdag 16 november 2017 heeft Lalin Kovudhikulrungsri haar proefschrift ‘The Right to Travel by Air of Persons with Disabilities’ verdedigd. Haar promotoren zijn Prof.dr. P.M.J. Mendes De Leon en Prof.mr.dr. A.C. Hendriks.
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A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions
Op donderdag 16 november 2017 is Thomas Leclerc gepromoveerd op zijn proefschrift ‘A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions. Contribution to the Study of Interactions between Legal Orders of International Law’. Zijn promotoren zijn prof.dr. P.M.J. Mendes De Leon en prof. L.…
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Legal Implications of Airport Privatization in India
Op donderdag 24 november 2016 promoveert Moses George op zijn proefschrift 'Legal Implications of Airport Privatization in India'. De verdediging vindt plaats om 11.15 uur in het Academiegebouw van Universiteit Leiden. De promotores zijn professor Pablo Mendes De Leon en professor Brian F. Havel (DePaul…
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Sylvestre Bonnet
Wiskunde en Natuurwetenschappen
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Artsen en burgers onder vuur in conflictgebieden
Het is tijd dat de internationale gemeenschap een halt toeroept aan oorlogsmisdaden - in het bijzonder tegen medisch personeel. Dat zei internationaal voorzitter Joanne Liu van Artsen zonder Grenzen tijdens de Cleveringa-oratie.
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Cleveringa-hoogleraar Liu weet hoe je ebola de baas wordt
Op donderdag 24 november gaf Joanne Liu een extra lezing over ebola in het Leids Universitair Medisch Centrum (LUMC). Dat deed zij voorafgaand aan haar Cleveringa-oratie op 25 november.
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Onze Medewerkers
Het Leiden Leadership Centre is een interdisciplinaire netwerkorganisatie. Als onderdeel van het Instituut Bestuurskunde van de Universiteit Leiden neemt het LLC een verbindende rol op zich door samen te werken met studenten, professionals uit de praktijk en wetenschappers vanuit verschillende disci…
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Improvisations in phototrophy
Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.
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Natural Products Lab
Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Anjali Pandit
Wiskunde en Natuurwetenschappen
a.pandit@chem.leidenuniv.nl | +31 71 527 4198
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Kerk, kolonialisme en slavernij: Verhalen van een vervlochten geschiedenis
In ‘Kerk, kolonialisme en slavernij’ belichten Bente de Leede en Martijn Stoutjesdijk de relatie tussen het christendom en slavernij door de eeuwen heen, aan de hand van casussen uit de Nederlandse geschiedenis.
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Insight in the role of lipids and other systemic factors in hand and knee osteoarthritis
Promotie
- Professor by special appointment Transatlantic Environmental History
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.