Promotie

Promovenda Jiangnan Ding onderzoekt hoe je een blok rubber zo kunt ontwerpen dat het dienst kan doen als een mechanische computerbit. Zo'n zogenaamd mechanisch metamateriaal wordt op een specifieke manier samengeperst om de vorm te veranderen. ‘Met een heel eenvoudig materiaal kunnen we in de toekomst…

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Martin van Hecke en Anne Meeussen publiceren in het tijdschrift Nature over mechanische metamaterialen. Ze hebben een nieuwe klasse multistabiele materialen ontdekt. Dit is gebaseerd op ribbeltjes plastic.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Promotie

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Het onderzoek van het Resilience Center gaat over geestelijke gezondheidsrisico's en veerkracht bij jongeren. We doen dit door culturele, sociale, cognitieve en neurobiologische factoren en hun interacties te integreren.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Wat is er nodig om een mens te maken? Een uitdijend heelal. Gebouwd uit deeltjes, ruimte en tijd, en hun subtiele mechanismen.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

De organisatie voor Economische Samenwerking en Ontwikkeling (OESO) heeft in samenwerking met het Inter-American Center of Tax Administrations (CIAT) op 27 november 2023 een wereldwijde online Tax Morale Workshop georganiseerd, waar Esther Huiskers-Stoop van de Universiteit Leiden en Diego Quiñones…

Somatische symptomen, zoals pijn, jeuk en vermoeidheid, blijken in twee richtingen samen te hangen met psychische symptomen. Hoewel acute somatische symptomen bepaalde adaptieve eigenschappen hebben, kunnen chronische symptomen in plaats daarvan leiden tot verstoring van dagelijkse activiteiten en vermindering…

De programmagroep verzorgt onderwijs op het gebied van diagnostiek, behandeling/preventie/interventie, neuropsychologisch onderzoek, gedragsobservaties, klinische vaardigheden, gesprekstechnieken, ondersteuning van leerkrachten en ouders, kennis over verstandelijke beperkingen en ontwikkelingsstoornissen…

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotor: V. Vitelli, Co-promotor: J. Paulose

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The focus of the dissertation

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: Roeland M.H. Merks