Promotie

Promotie

Promotor: E.F. Smets, Co-promotor: J. Geml

Promotor: E.F. Smets Co-promotor: J. Geml

Promotie

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Lezing

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Herstel van de natuur op uitgeputte landbouwgrond en in natuurgebieden verloopt moeizaam. ‘Bodemtransplantatie’ kan mogelijk uitkomst bieden. Dat betoogt Martijn Bezemer, hoogleraar Ecologie van Plant-Microbe-Insect interacties. Oratie op 18 december.

Muziek van een composteerbare cello, foto’s en geurtjes van schimmels en een geweven wandkleed. Het zijn een aantal voorbeelden uit Super Organism, het kunstproject van Suzette Bousema waarin je de ondergrondse schimmelwereld met al je zintuigen kunt beleven. Leids milieuwetenschapper Nadia Soudzolovskaia…

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotie

Promotie

Promotie

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Elk onderdeel van de kringloop op een melkveebedrijf heeft een specifieke bacterie- en schimmelsamenstelling. Dat ontdekten de Leidse postdoc onderzoeker Sofia Gomes en haar begeleiders Nadia Soudzilovskaia en Peter van Bodegom in samenwerking met het Louis Bolk instituut en Naturalis Biodiversity Centre.…

Promotie

Promotie

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Op dinsdag 17 maart promoveert Robert Rissmann van het LACDR. De titel van zijn proefschrift luidt

Projecten van de afdeling Environmental Biology

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Gisteren verscheen er een artikel in Biznews over het watertekort in California. David Zetland, universitair docent aan het Leiden University College The Hague, gaf zijn mening over dit probleem.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Lezing

Promotie

Vooral neerslag en bodemzuurgraad bepalen welke microben in een bepaalde habitat overleven en welke niet. Deze kennis is van belang om de biodiversiteit in stand te houden. Leidse milieukundigen werkten mee aan het onderzoek. Publicatie in Nature op 1 augustus.

Promotie

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotie

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

Mark Klaassen, universitair docent immigratierecht, trad onlangs als spreker op tijdens het Reuniting Families: From Access to Integration congres dat werd georganiseerd door het EU-kantoor van het Rode Kruis in Brussel.

How can we quantify the density of species within a community through environmental DNA concentrations?

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Supervisor: P.J.J. Hooykaas

Mycorrhizas are symbiotic associations between soil fungi and most plant species.