Kasteren

Promotores: H.A. Udo De Haes, P.M. Brakefield

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Overkleeft

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Dr. Remko Offringa is met ingang van 1 september 2016 benoemd tot Opleidsingsdirecteur van de masteropleiding Biology. Hij volgt daarmee Johan Memelink op.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.

Promotor: Prof.dr.ir. E. Deprettere

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Meer leren over het ontstaan van het leven op Aarde? Dat kan in de Summerschool Crises in Biology.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Op 3 oktober streed een team van het Instituut Biologie Leiden tegen andere universitaire biologenteams in de Biology Battle of the Universities. Het team behaalde de tweede plaats.

Prof.dr. Geert de Snoo is per 1 maart bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Conservation Biology. De Snoo blijft hoofd van de gelijknamige afdeling van het Institute of Environmental Sciences (CML).

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

In het kader van de Honours Course ‘Crises in Biology’ die plaatsvond van 19 augustus t/m 2 september 2012 in Normandië, bezochten studenten vele geologische interessante locaties. Een van deze bijzondere plekken was de kust van Arromanches. Hier bemachtigden zij een enorm grote ammoniet die ze dinsdag…

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Wetenschappers van de Universiteit Leiden hebben een doorbraak bereikt in de bestudering van de erfelijke stofwisselingsziekte van Pompe. Samen met hun Yorkse collega’s ontwierpen zij een molecuul dat zich bindt aan het enzym dat aan de basis staat van het ziekteverloop. De bevindingen zijn gepubliceerd…

Promotie

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals