Promotores: H.W. Lenstra, A. Lucchini

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotor: S.M. Verduyn Lunel

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotor: B. van de Water

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotor: J.W.M. Frenken

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Students Practicing Citizen Journalism

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Promotores: H. Schiessel, G.T. Barkema

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky