1,171 zoekresultaten voor “this work e2 80 99s discovered” in de Publieke website
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Patterns of coral species richness and reef connectivity in Malaysia
Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Neonicotinoids in nature: The effects on aquatic invertebrates and their role in ecosystems
This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Development of life cycle assessment for residue-based bioenergy
Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Don't Blink: Detecting transiting exoplanets with MASCARA
This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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Governance of Innovation Project Management: Necessary and Neglected
Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries
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Lectureship in the Political Economy of Japan (1,0 fte)
Geesteswetenschappen, Institute for Area Studies, Japanese Studies
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After Work Conversations
Symposium
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All-gender toilet Plexus
Studentencentrum Plexus, Kaiserstraat 25, 2311 GN, Leiden
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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A time-space translation mechanism for patterning the vertebrate anteroposterior axis
My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Multi-objective mixed-integer evolutionary algorithms for building spatial design
Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.
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Combining monitoring with run-time assertion checking
Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue
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Linkages of Sustainability
Exploring linkages between energy and material use and implications for sustainable development.
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Onderzoeker Verlinde van Princeton University geeft lezing ‘This Week’s Discoveries’ op 1 juni
De titel van de lezing is ‘On the Emergence of Space and Gravity’, de lezing is openbaar, Engelstalig en duurt speciaal voor deze gelegenheid een half uur, i.p.v. van het gebruikelijke kwartier voor de This Week’s Discoveries lezingen.
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This Week’s Discoveries over het redden van haantjes en de nobelprijs voor het higgsdeeltje
Deze week wordt de eerste lezing verzorgd door bioloog Wouter Bruins, de haantjesredder. Met zijn bedrijf In Ovo stond Bruins deze week op de 16e plaats in de 'Duurzame 100' van dagblad Trouw.
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Full Professor (Universitair Hoogleraar) of International Relations
Geesteswetenschappen
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Post-Doctoral Researcher: Intelligence in the Global South (1,0 FTE)
Governance and Global Affairs, Institute of Security and Global Affairs
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Managing group work (voertaal Engels)
Didactiek
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Looking Beyond Our Similarities
How Perceived (In)Visible Dissimilarity Relates to Feelings of Inclusion at Work
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PhD Candidate in Social Norms and Gender Inequalities in the Labour Market (0.8-1.0 fte)
Rechtsgeleerdheid
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Postdoctoral Researcher in the project "Do we owe anything to ourselves?"
Sociale Wetenschappen, Psychologie
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Postdoctoral researcher in African Studies
Afrika-Studiecentrum Leiden
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Studeren aan Universiteit Leiden
Ben jij klaar voor de maatschappelijke uitdagingen van nu en in de toekomst? Bij Universiteit Leiden word je opgeleid om verschil te kunnen maken in de samenleving. Samen beantwoorden we de vragen van vandaag en houden we de blik gericht op morgen. Met keuze uit meer dan 50 bacheloropleidingen en ruim…
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Studying dark matter using weak gravitational lensing : from galaxies to the cosmic web
Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).
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Studeren aan Universiteit Leiden
Ben jij klaar voor de maatschappelijke uitdagingen van nu en in de toekomst? Bij Universiteit Leiden word je opgeleid om verschil te kunnen maken in de samenleving. Samen beantwoorden we de vragen van vandaag en houden we de blik gericht op morgen. Met keuze uit meer dan 50 bacheloropleidingen en ruim…
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PhD Candidate in Economics (0.8-1.0 fte)
Rechtsgeleerdheid
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PhD Position on Understanding the Global Movement for Open Research Information
Sociale Wetenschappen, Centrum voor Wetenschaps- en Technologiestudies
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Organisational & Entrepreneurial Behaviour
De onderzoeksgroep Organizational & Entrepreneurial Behavior onderzoekt het gedrag van individuen en groepen die in organisaties werken, organisaties starten, of organisaties leiden, met als doel om organisatorische praktijken te informeren. Door zich te concentreren op het gedrag van (groepen) werknemers,…
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Post-doctoral researcher (1.0 FTE; 24 months)
Governance and Global Affairs, Institute of Security and Global Affairs
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Evaluatie en implementatie van innovatieve diagnostiek en behandelingen
Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…
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Internship information
An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.
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Contact
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Voorspelbare variatie in medicijndoseringen voor kinderen
C Knibbe
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Peptide Facility
Peptiden worden routinematig gesynthetiseerd in het bereik van 5-80 aminozuren, in een hoeveelheid van 1-200 µmol (kleinere en grotere hoeveelheden zijn ook mogelijk).