Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Aan de hand van de boekenserie General History of Africa (GHA) onderzocht promovenda Larissa Schulte Nordholt wat het betekent om de geschiedenis van Afrika te dekoloniseren. Dat bleek een moeizaam proces, waarbij politiek en financiën voor belemmeringen zorgden. Promotie 1 december.

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Leidse wetenschappers gaan een bijdrage leveren aan de ontwikkeling van een camera voor de in aanbouw zijnde European Extremely Large Telescope. Op 28 september tekende de Nederlandse Onderzoekschool voor Astronomie een samenwerkingsovereenkomst met de European Southern Observatory.

Het huidige TBC-vaccin biedt niet voldoende bescherming meer. Een Europees consortium gaat daarom proberen een nieuw vaccin te ontwikkelen. Hiervoor ontvangen zij een Horizon2020-subsidie van 18 miljoen euro. Bijna een miljoen euro hiervan gaat naar het LUMC.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Kim de Jong, Jaime Delgadillo en Michael Barkham bieden waardevolle inzichten in hun boek 'Routine Outcome Monitoring and Feedback in Psychological Therapies' over hoe therapeuten en stagiaires feedback kunnen gebruiken om beslissingen over behandelingen te onderbouwen en uiteindelijk de resultaten…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: G.R. de Snoo

Promotor: R. Gill, Co-promotor: P. Massart

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

How can we bridge the gap between experts and the general public?

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Het College van Bestuur heeft Herman Paul (Instituut voor Geschiedenis) per 1 januari 2019 benoemd tot hoogleraar Geschiedenis van de geesteswetenschappen.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Jos Gommans heeft een subsidie van € 200.000,- van het Leids Universiteits Fonds (LUF) ontvangen voor onderzoek naar de ontwikkeling van religieuze en culturele tradities in Indonesië tussen 1600 en 1940.

Veteranenorganisaties verdraaien de uitkomsten van het onderzoek naar extreem geweld in de Indonesiëoorlog. Dat betoogt universitair docent Thijs Brocades Zaalberg met Rémy Limpach en Esther Zwinkels in een opiniestuk in NRC.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

De 260 jaar oude wetenschappelijke prijs van het Legatum Stolpianum wordt dit jaar toegekend aan twee goed geschreven historische studies van hoge kwaliteit, met actuele betekenis. Een van de winnaars is de Leidse classica Tazuko van Berkel.

Op 3 maart werd op een symposium aan de Vrije Universiteit in Amsterdam het boek “The European Union as an Area of Freedom, Security and Justice” onder redactie van Maria Fletcher, Claudio Matera en Esther Herlin-Karnell gepresenteerd.

This thesis focuses on the study of transient and variable radio sources in the universe.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

De masterspecialisatie Politics, Society and Economy of Asia van de Universiteit Leiden is gericht op studenten die één of meer landen of regio’s van modern of hedendaags Azië willen bestuderen vanuit het perspectief van de sociale wetenschappen.

1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…

In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.