The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

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The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Cognitieve psychologie is de studie van mentale functies, waaronder aandacht, geheugen, bewustzijn, emotie, taal en actiecontrole. Het doel is om de complexe relaties tussen brein, cognitie en gedrag te begrijpen.

Promotor: J. A. Bouwstra

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

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Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

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Promotor: Prof.dr. C.U. Keller

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Possible improvements for the assessment of abiotic depletion in LCA.

Religion, Philosophy, and the Pre-modern World

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

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Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.

De onderzoekers van het departement ‘World Archaeology’ van de Faculteit Archeologie richten zich in hun onderzoek op verschillende periodes en regio’s: van de oorsprong van de mens tot aan de Middeleeuwen en de moderne tijd, en van Azië tot Zuid-Amerika.

When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

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What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. E. F. van Dishoeck

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Promotor: Prof.dr. G.P. van Wezel

Cardiovascular syndromes are the major cause of death in Western societies.

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: A.W. van der Vaart

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne