5,559 zoekresultaten voor “history of science and the occurs” in de Publieke website
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.
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Accountability and data-driven urban climate governance
The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.
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On the 16-rank of class groups of quadratic number fields
Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)
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More JAZ in the orchestration of jasmonate-mediated plant defense
Prof.dr. J. Memelink
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Explicit Computation of the Height of a Gross-Schoen Cycle
Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Redox Interconversion between Metal Thiolate and Disulfide Compounds
In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.
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Molecular electronics: Controlled manipulation, noise and graphene architecture
Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.
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Discriminatory punishment undermines the enforcement of group cooperation
Enforcement of group cooperation fails because of discriminatory punishment, according to research by Welmer Molenmaker and colleagues. When group members have different backgrounds, punishment turns into a double-edged sword: no longer used just to prevent group exploitation, but also to break the…
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Good practices in the Caribbean: rechtshandhaving en rechtstaat
De centrale vraag is wat Nederland kan leren van de wijze waarop deze landen de rechtshandhaving en de rechtstaat in hun overzeese gebieden hebben ingericht.
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Implementation of the EU Preventive Restructuring Directive Part I
In 2019 hebben het Europees Parlement en de Raad de Richtlijn Preventieve Herstructurering (2019/1023) aangenomen, die voorziet in minimale harmonisatie van onder andere preventieve herstructureringskaders (preventive restructuring frameworks, 'PRF'). Dit boek biedt verdiepende analyses van de implementatie…
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Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.
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Prying eyes on radio skies: pushing the high-resolution low-frequency frontier with LOFAR
In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.
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The Duke-Leiden Institute in Global and Transnational Law: Call for Applications 2019
The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 16 June to 17 July 2019 in The Hague, the International City of Peace and Justice. Applications for the second edition are now open!
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MINESCAPES: Socio-natural Landscapes of Extraction and Knowledge in the Middle Ages and the Early Modern Period
MINESCAPES invites PhD students from various disciplines to apply for participation in their 2024 summer school, taking place from May 31 to June 10, 2024. The Summer School will bring together students and scholars from the humanities, social sciences, and natural sciences to study mining landscapes…
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Size effects in microstructured superconductors and quantum materials
We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Selective and efficient electrochemical CO2 reduction on nanostructured catalysts
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Photography meets Science and the City
Congres/symposium
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Paul Scholten. Book chapter in Great Christian Jurists in the Low Countries
Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in
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Labour Law and Development in Indonesia
De ontwikkeling en versterking van sociale rechten en rechten van arbeiders in Indonesië weerspiegelt de bredere processen van sociale en politieke hervormingen in het land.
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Research and design in STEM education
Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…
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Cyber-noir: Cybersecurity and popular culture
Een nieuw artikel over de invloed die populaire cultuur uitoefent op cybersecurity experts. Beschikbaar als Open Access artikel bij 'Contemporary Security Policy', als onderdeel van een speciale editie die is samengesteld door dr. Myriam Dunn Cavelty.
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Suppressing a Sea of Starlight: Enabling technology for the direct imaging of exoplanets
Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik
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Development of new chemical tools to study the cannabinoid receptor type 2
The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.
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Een gedreven buitenstaander: J.H. van 't Hoff de eerste Nobelprijswinnaar voor Scheikunde
This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…
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Triple bottom line approach for risk-benefit analysis of genetically modified crops
Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.
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Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Chemical synthesis of fragments of galactosaminogalactan and pel polysaccharides
The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.
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Applications of topology to Weyl semimetals and quantum computing
This thesis covers various applications of topology in condensed matter physics and quantum information.
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Reliable and Fair Machine Learning for Risk Assessment
The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.