Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Het onderzoek van de programmagroep Onderwijswetenschappen richt zich op ‘het lerende kind in het onderwijs’. De focus ligt op processen die plaatsvinden tijdens de ontwikkeling en het leren.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

Al het onderzoek van de Universiteit Leiden is georganiseerd in instituten. Om recht te doen aan de veelkleurigheid van het onderzoek (en dus ook aan het onderwijs) dat daar uit voortvloeit vindt u op deze pagina’s omschrijvingen van alle Leidse instituten.

Control of infectious diseases poses continuous challenges for human health.

Bepaalde ontwikkelingsfases en specifieke problemen van kinderen, zoals somberheid en angsten, vragen om specifieke benaderingen, waar ouders steeds opnieuw vorm aan moeten geven. Hoe wordt onderzoek naar ouderschap en de invloed hiervan op het welzijn van kinderen vormgegeven, en wat valt hiervan te…

Deze minor richt zich op de cognitieve processen die invloed hebben op de wisselwerking tussen brein en bewustzijn.

In this course, you will develop an understanding of evolutionary processes and their formative power. You will see how evolution has shaped biodiversity, and continuously influences our daily life.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

The research programme Cities, Migration and Global Interdependence 1350-2000 (CMGI) focuses on urbanisation, migration, and economic development in a comparative and global context.

De chemische sector moet blijven vernieuwen voor een duurzamere en gezondere samenleving. De onderzoekers van het Leids Instituut voor Chemisch onderzoek (LIC) dragen daaraan met hun onderzoek en onderwijs bij door in te zetten op de thema’s duurzaamheid, energie en gezondheid.

Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?

BioSolar Cells is a five-year research project in which ten knowledge institutions and 45 private industries work together.

Het begrijpen van individuele verschillen in zelfregulatie bij jongens met ODD/CD op het niveau van het brein, cognitie en gedrag

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Promotor: A. Kros

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Planets are formed in disks of gas and dust around young stars.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Deze serie benadert begrijpend lezen vanuit een cognitief perspectief. We beschrijven hoe lezers tot begrip komen. Dat wil zeggen: hoe zij coherente mentale representaties opbouwen tijdens het lezen van tekst.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: Prof.dr. T. Schmidt

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa