This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. J. den Hertog

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

An interdisciplinary collection of the best international scholarship on Muslim youth.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Development of indicators to assess decoupling of economic development and environmental pressure in the EU-25 and AC-3 countries.

Spontaan elkaar helpen, waarom is dit belangrijk? Het is bekend dat elkaar helpen bijdraagt aan een betere sociale band en goede contacten, en vriendschappen bestendigt. In deze studie voerden we een experiment uit waarin de onderzoeker 'per ongeluk' lucifers liet vallen. De meeste tieners hielpen mee…

Werken bij een topfaculteit? Ontdek de vacatures bij Wiskunde en Natuurwetenschappen en solliciteer meteen.

In een longitudinale studie onderzochten Adva Eichengreen en collega's hoe aspecten van emotionele intelligentie de ontwikkeling van de geestelijke gezondheid van adolescenten beïnvloeden. Zo identificeerden ze potentiële waarschuwingssignalen en doelen voor interventieprogramma's.

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Publicaties die voortkomen uit het AFITE-project

Een signaal dat zowel in het centrum van ons Melkwegstelsel voorkomt, als op afgelegen plekken in het heelal, laat mogelijk de oorsprong van donkere materie zien. Dat concludeert de Leidse natuurkundige Alexey Boyarsky in een artikel in Physical Review Letters.

Review of new technical decisionsupport systems in the environmental field, and application in water management decission processes.

Ingewikkelde theorie en een moeilijke toets hebben bij studenten in Leiden vaak de voorkeur boven een practicum. Toch is universitair docent Paul Logman van mening dat studenten veel leren van practicumonderwijs. Hij daagt zijn studenten uit om hun eigen onderzoek te bedenken. Het Leids Instituut voor…

Metingen aan een supergeleider laten een scherpe overgang zien tussen een gewoon metaal en een zogeheten 'vreemd' metaal. Maar wat pas echt vreemd is: de overgang verliest die scherpte weer als de temperatuur daalt. Theoretisch natuurkundige Jan Zaanen, een van de auteurs van een Science-artikel: 'We…

De Universiteit Leiden biedt een specifieke masteropleiding die kolonialisme en slavernij behandelt.

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

This thesis is about cosmological inflation and its relation to observations.

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

n this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotie

Promotie

Waterdruppels zweven in een hete pan vanwege het zogenoemde Leidenfrost-effect. Nu hebben natuurkundigen een variatie ontdekt: het Elastische Leidenfrost-effect. Het verklaart waarom hydrogel balletjes op een hete plaat rondspringen en hoge piepgeluidjes maken. Publicatie in Nature Physics op 24 jul…

Hoe complexer het voorwerp, des te ingewikkelder het is om op te vouwen. Een ruimtevaartuig heeft al snel vele motortjes nodig om een instrument-arm in elkaar te vouwen en mensen hebben zelfs moeite met een wegenkaart. Natuurkundigen uit Leiden en Amsterdam hebben nu een structuur ontworpen die zichzelf…