Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: Prof.dr. T.H.W. Bäck

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

This interdisciplinary study focuses on (trans)national ethnic and popular networks, combining historical-ethnographic and computational methods to understand the ‘workings’ of networked conflict interfering in the increasingly violent conflict in the Sahel (Africa) and beyond. The project focuses on…

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

Planeten in andere zonnestelsels bevatten waardevolle informatie over het ontstaan van planeten en leven. Promovenda Yapeng Zhang heeft hun atmosferen bestudeerd door te kijken naar hun kleinste onderdelen: isotopen. Met haar onderzoek hoopt ze te ontdekken wat ons eigen zonnestelsel uniek maakt.

Tijdens het bestuderen van zestien jaar aan meetgegevens van jonge sterren ontdekte de Leidse masterstudent Sam de Regt dat twee van die sterren nog gehuld waren in geboortewolken. Nog niet eerder bracht iemand deze twee sterren zo scherp in beeld. Hij publiceert zijn opschoonmethode en de nieuwe afbeeldingen…

In de afgelopen 30 jaar zijn er ruim 5000 planeten ontdekt buiten ons zonnestelsel. Een veelvoorkomende exoplaneet is de lavawereld, een hete superaarde met oceanen van vloeibaar lava. Mantas Zilinskas ontwikkelde modellen om mogelijke atmosferen daarvan te simuleren. Die simulaties bieden houvast voor…

De 'Kluitersprijs' wordt jaarlijks uitgereikt aan studenten die excellente resultaten behalen in de minor Intelligence Studies.

Lees hier alles over de extra financiële middelen die de Rijksoverheid beschikbaar stelt vanuit het Nationaal Programma Onderwijs.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.