Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Het FAIRDOM-consortium is een open initiatief van verschillende partners, waaronder financieringsprogramma's, grote consortia, instituten, kleine groepen en individuen.

Op 19 december 2024 is de monografie van Dr. Constanta Rosca, 'Digital Arms for Digital Consumer Harms: Mapping Legal and Technical Solutions for Dark Patterns in EU Consumer Law', als open access boek gepubliceerd.

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Hetterscheid

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: B.van de Water, Co-promotor: L.S.Price

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Het centrale doel van dit proefschrift is inzicht verschaffen in hoe de implementatie van een peer educator-interventie van invloed kan zijn op de houding van leerlingen tegenover LHBT-leeftijdgenoten en op de relatie tussen deze houdingen en reflectie over burgerschap.

Het Centre for Professional Learning van Universiteit Leiden en de Public Affairs Academie presenteren een nieuw verdiepend programma voor ervaren PA-professionals. Dit najaar bieden CPL en de Public Affairs Academie samen een uniek programma voor senior public affairs-professionals.

In november is het project ‘Academie voor Professionals’ van start gegaan. Hierin wordt ingezet op de verdere ontwikkeling van bestaand en nieuw onderwijsaanbod voor professionals. ‘Als je valorisatie serieus neemt dan hoort dit er gewoon bij.’

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Promotor: Prof.dr. P. Stevenhagen

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…