The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

The key purpose of this project is to study tautological relations on the level of closed differential forms or even integral cochains (i.e. we don't take classes in cohomology).

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: Prof.dr. P.C. van Welzen

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

We consider the propagation of electrical signals through nerve fibres.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotor: Prof.dr. H.S. Overkleeft

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Bas Edixhoven, Promotor: Qing Liu

Promotores: W. Jiskoot, F. Ossendorp

This dissertation presents new cryptographic protocols, which can be divided into two families.

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Control of infectious diseases poses continuous challenges for human health.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Scheikunde of chemie is de natuurwetenschap die zich bezighoudt met de samenstelling en bouw van stoffen, chemische veranderingen bij bepaalde omstandigheden en de wetmatigheden die je hieruit kunt destilleren.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Er is veel persaandacht voor het onderzoek van het Levend Lab. Hieronder een kleine greep uit de nieuwsberichten. En bekijk ook vooral de Zembla-aflevering over het Levend Lab.

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Possible improvements for the assessment of abiotic depletion in LCA.

Vooral neerslag en bodemzuurgraad bepalen welke microben in een bepaalde habitat overleven en welke niet. Deze kennis is van belang om de biodiversiteit in stand te houden. Leidse milieukundigen werkten mee aan het onderzoek. Publicatie in Nature op 1 augustus.

Projecten in de afdeling Industrial Ecology