Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Promotor: A. Kros

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Promotores: W. Jiskoot, F. Ossendorp

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: Prof.dr. P. Stevenhagen

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

We consider the propagation of electrical signals through nerve fibres.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Studievoorlichting

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

Lezing

Deze zomer is het heelal dichterbij dan ooit. Met het online zomerprogramma ‘Ruimtevaart in je Woonkamer!’, brengt de Leidse Sterrewacht astronauten en Leidse astronomen naar huizen van kinderen in heel Europa.

Geesteswetenschappen, Institute for Area Studies

Geesteswetenschappen, Institute for Area Studies

Lezing

Promotie

Promotie

Promotie

De hoogte van het collegegeld is afhankelijk van een aantal dingen: uit welk land je afkomstig bent, welke opleiding je doet en of je eerder al eens een opleiding hebt afgerond.

Wil je graag wat extra’s doen naast je studie? Kies dan een dubbele bachelor van Sterrenkunde met Natuurkunde of Wiskunde. Ook kun je aan het honoursprogramma deelnemen.

Wil je graag wat extra’s doen naast je studie? Kies dan een dubbele propedeuse of dubbele bachelor van Natuurkunde met Sterrenkunde of Wiskunde. Ook kun je aan het honoursprogramma deelnemen.

Promotor: H.J.M. de Groot

Promotor: Prof.dr. H.S. Overkleeft

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot