In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

What invertebrates live in the fields and edges? Do the populations change with landscape complexity?

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

In this thesis integral points on affine del Pezzo surfaces are studied.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Does a high quality prairie restoration in an urban/agricultural landscape provide invertebrates necessary for a sustainable ecosystem?

Promotores: H. Schiessel, G.T. Barkema

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotor: Prof.dr. E. F. van Dishoeck

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: T.H. Oosterkamp

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: Prof.dr. G.P. van Wezel

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: J. Kuiper

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Promotor: Prof.dr. A. Achucarro

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: Prof.dr. P.C. van Welzen

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Prof.dr. J. Kuiper

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.