729 zoekresultaten voor “middle all” in de Publieke website
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Aspects of Record Linkage
Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft
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Contributions to the phylogeny of the haplolepideous mosses
The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…
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Genetic diversity in the lion (Panthera leo (Linnaeus 1758)): unravelling the past and prospects for the future
Promotor: Prof.dr. G.R. de Snoo
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Surface Temperature and the Dynamics of H2 on Cu(111)
Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…
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RAISE Onderzoek
Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…
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Constraint-Based Analysis of Business Process Models
Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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DNA expressions - A formal notation for DNA
Promotores: J.N. Kok, H.J. Hoogeboom
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Spin dynamics in general relativity
Promotor: J.W. van Holten
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Dynamical Gibbs-non-Gibbs transitions and Brownian percolation
Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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RaMa-SCENE
A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy
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Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
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Cross-border Claims to Cultural Objects
Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Inverse problems for universal deformation rings of group representations
Promotor: Prof.dr. P. Stevenhagen
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Applications of AdS/CFT to strongly correlated matter: from numerics to experiments
What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Neutrinos From the Milky Way
Promotor: Prof.dr. M. de Jong
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Radicals in arithmetic
Promotor: Prof.dr. P. Stevenhagen, Co-promotor: B. de Smit
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Women Writing Mexico (WWM)
Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…
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LUMC Onderwijsgebouw
Hippocratespad 21, Leiden
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Pushing the characterization of exoplanet atmospheres down to temperate rocky planets in the era of JWST
One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.
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Hier heb je mijn Turkse medaille terug, Erdogan
Erik-Jan Zürcher kreeg in 2005 een Turkse onderscheiding voor het voorlichten van Nederland over Turkije. Nu geeft hij zijn medaille terug. „Ik had het bij het verkeerde eind. Turkije kan geen deel uitmaken van Europa.”
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eHealth for all? Towards usable and effective eHealth services in different health care settings
Promotie
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Workshop vroege fotografie van het Midden-Oosten - In contact met collecties
Workshop
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2012 Even voorstellen: Catherina Wilson
Catherina Wilson is op 1 oktober 2012 aan ons Instituut begonnen met een promotieonderzoek.
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Manuscript Lecture in Leiden University Library: Erik Kwakkel (May 7)
Professional scribes in the Middle Ages produced advertisement sheets with which they presented themselves to potential clients. In this lecture Erik Kwakkel will show known and new examples of such advertisement sheets and interpret their importance for our understanding of the culture of writing in…
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FAQ Klinische specialisaties Master Psychologie
Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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The Infrared Spectrum of Massive Protostars
We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.
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The mixed Ax-Lindemann theorem and its applications to the Zilber-Pink conjecture
Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)
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Explorations of Water Oxidation Catalysis in Explicit Solvent
In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.
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Systematics, Epidermal defense and Bioprospecting of Wild Orchids
This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.
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The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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The evolution of shell form in tropical terrestrial microsnails
Promotor: Prof.dr. M. Schilthuizen