Promotor: J.N. Kok, Co-promotor: M.S. Lew

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Promotor: E.F. Smets, Co-promotor: J. Geml

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: Prof.dr. S. Portegies Zwart

Ongeveer een derde van de ouders en jonge kinderen (van 0 – 4 jaar) hebben na de eerste nationale lockdown van 2 maanden stress ervaren bij de terugkeer naar het kinderdagverblijf, zoals gerapporteerd door ouders in een grootschalig online vragenlijstonderzoek.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

A scenario building web-tool and knowledge package to enable multi-level decision making for the transition to the Circular Economy

Promotor: J.W. van Holten

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Enkele keren per jaar organiseert het Europa Instituut een ‘Meet the Author’ bijeenkomst. In het kader van deze nieuwe lezingenreeks komen externe academici naar Leiden om te spreken over een recente publicatie. ‘Meet the Author’ bijeenkomsten vangen aan met een gesprek tussen een lid van het Europa…

The specialisation Science Communication and Society (SCS) concerns science communication in a broad sense. The program focuses on the link between science and society and covers knowledge and skills in the field of science communication.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Prof.dr. B. van de Water

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

What impact does a mid-season wildfire have on grassland invertebrates?

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotor: Prof.dr. F. den Hollander, G.Maillard

CMLCA is a software tool that supports the technical steps of the Life Cycle Assessment. The focus of the program is on advanced computational aspects of life cycle inventory calculations.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans