Jeugdrecht en Gezondheidsrecht is volop in ontwikkeling en speelt een rol bij tal van maatschappelijke kwesties, zoals kindermishandeling, jeugdzorg en jeugdcriminaliteit.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotores: G.A. Persoon, H.H. de Iongh

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Prof.dr. J.W.M. Frenken

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Als mensen hebben we de neiging om bepaalde handelingen als goed of fout te beoordelen. Waar komt ons morele besef vandaan? We hebben bewijs gevonden dat baby's van slechts één jaar oud de voorkeur geven aan degenen die troosten in plaats van negeren wanneer iemand verdrietig is.

Religious Studies at Leiden University allows you to study a broad spectrum of religions and their manifestations.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Studievoorlichting

Promotie

Promotie

Lezing, Publiekslezing

Een onderzoek naar moord en doodslag.

Inzicht in de beweegredenen van de foreign fighters om te gaan vechten in oorlogsgebieden en het analyseren van sociale omgeving biedt handvatten om te voorkomen dat ze vertrekken.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

In this thesis integral points on affine del Pezzo surfaces are studied.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Delineating psychophysiological endophenotypes of social anxiety disorder

Brieven en dagboeken geven in dit boek een inkijk in het hofleven rond Willem I en tonen de verstrengeling van dat hofleven met landsbestuur en politiek.