Milieuwetenschapper Nadia Soudzilovskaia heeft de prestigieuze, internationale Bessel-Forschungs-prijs van de Von Humboldt-stichting gewonnen. Deze Duitse prijs wordt uitgereikt aan uitmuntende buitenlandse wetenschappers die middenin hun carrière staan en samenwerken met Duitse onderzoekers. ‘Het is…

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The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Planten zou je kunnen zien als kleine chemische fabrieken, die via fotosynthese chemische stoffen produceren. Als we fotosynthese kunnen nabootsen in een kunstmatig systeem, kunnen we schone brandstoffen en materialen maken uit zonlicht en CO2. Huub de Groot is heel dicht bij het ontwerpen van zo’n…

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

De Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) heeft landelijk 159 jonge, recent gepromoveerde onderzoekers een Veni-subsidie toegekend. 19 onderzoekers zijn verbonden aan de Leidse universiteit, waarvan 5 aan de Faculteit der Wiskunde en Natuurwetenschappen. Elke onderzoeker krijgt…

Ziekteverwekkende bacteriën zijn steeds vaker resistent voor de huidige antibiotica. De vraag naar nieuwe antibiotica wordt daarmee steeds groter. Professor Gilles van Wezel zoekt naar nieuwe vormen van antibiotica in goede bacteriën die in de grond leven.

Op het terrein van de Hortus staat de Oude Sterrewacht. Deze Sterrewacht is het oudste nog bestaande universitaire observatorium ter wereld. Sinds 1633 gebruikt de Universiteit Leiden de verschillende ruimtes voor onderwijs aan studenten. Het bezoekerscentrum beneden in de Oude Sterrewacht is onderdeel…

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: V. Vitelli, Co-promotor: J. Paulose

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Planets are formed in disks of gas and dust around young stars.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Cardiovascular syndromes are the major cause of death in Western societies.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Sustainable energy from wind and solar is most readily available near the sea.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal