2,200 zoekresultaten voor “specifiek for a” in de Publieke website
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PhD: Targeting electron transport chain in Listeria monocytogenes for novel antibiotic development
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Sovereignty as a Vocation in Hobbes's Leviathan
Hoye stelt dat het fundamentele fundament van Hobbes' Leviathan grootmoedige staatkunde belichaamt, waarin soevereinen natuurlijke rechtvaardigheid nastreven, die zich manifesteert als eminente
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Public perception of terrorism attacks: A conjoint experiment
Dit artikel onderzoekt de publieke perceptie van terroristische aanslagen door het belang te meten dat het publiek toekent aan kenmerken van terroristische aanslagen.
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Customary Authorities and Environmental Governance in Africa: A Systematic Review
Deze systematische review van 68 Engelstalige artikelen onderzoekt de rol van gewoonterechten in het milieubeheer in Afrika bezuiden de Sahara.
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Evaluation of Different Design Space Description Methods for Analysing Combustion Engine Operation Limits
Promotor: Prof.dr. T.H.W. Bäck
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Genomics applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-criteria optimalisatie is een effectieve techniek voor het vinden van optimale oplossingen die een afweging bieden tussen verschillende, tegenstrijdige criteria. Het heeft zijn toepassing gevonden in de wereld om ons heen omdat bij het oplossen van praktische, re¨ele wereld problemen men gewoonlijk…
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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The galaxy–dark matter connection: a KiDS study
In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Automated machine learning for dynamic energy management using time-series data
Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
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A Disobedient Diaspora: Living Hinduism in Osdorp, Amsterdam
Dit project onderzoekt het religieuze leven van een Surinaamse Hindoegemeenschap die in Amsterdam praktiseert in de Sri Radha Krishna Mandir vanuit een interdisciplinair perspectief.
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SFA of Chlorine in Europe: A MacTempo Case-Study
An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.
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Tom van der Meer e.v.a., ‘De kiezer’
Nederlandse politicologen laten hun licht schijnen over het veranderende electoraat.
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Old Age in Early Medieval England, A Cultural History
Hoe dachten de anglosaksen over de ervaring van het ouder worden? Was het echt een gouden tijd voor de ouderen zoals werd gesuggereerd?
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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PhD candidate, Feature-based machine learning for precision diagnosis of neuromuscular diseases
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Strategies for braiding and ground state preparation in digital quantum hardware
With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.
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Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Three-dimensional simulation models of plant tissue mechanobiology (1.0 FTE for three years)
Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)
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Individual teacher learning in a context of collaboration in teams
In dit proefschrift staat het leren van ervaren docenten in een context van samenwerking in interdisciplinaire teams centraal.
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine
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Children's Right to Health: a Living Reality?
Wereldwijd hebben miljoenen kinderen te maken met ziektes die relatief makkelijk te voorkomen zijn. Sarah Spronk onderzocht de vraag welke prioriteiten voortvloeien uit het recht op gezondheid van kinderen om vervolgens kindgerichte gezondheidszorg te kunnen vormgeven.
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Van Willigen, ‘A Dutch return to UN peacekeeping?’
Niels van Willigen (Instituut Politieke Wetenschap, Universiteit Leiden) plaatst de Nederlandse deelname aan VN vredesmissies in een historische context. Hij bekijkt de redenen voor een afname van de Nederlandse inbreng na 1990 en verkent de obstakels en mogelijkheden voor een ‘Nederlandse terugkeer’…
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Being a guest author for blogs/online reviews: why and how
How does one become a guest author for Nobel Prize winner Dr. Denis Mukwege Foundation? One of our alumni, Mariasole Forlani, can tell you all about it.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Triple bottom line approach for risk-benefit analysis of genetically modified crops
Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.