Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Universiteit Leiden doet op dit moment in samenwerking met Kenniscentrum Revalidatiegeneeskunde Utrecht onderzoek naar de digitalisering van cognitieve behandeling van patiënten. Het onderzoek bestaat uit een enquête en heeft het doel de zorgverlening efficiënter en makkelijker te maken. Daarom zijn…

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Cursus, Training

Promotor: A.P.IJzerman Co-promotor: A. Bender

Op 9 april promoveert Manolis Fragkiadakis. Het Leiden University Centre for Linguistics feliciteert Manolis!

Het Dual PhD Centre faciliteert duaal promotieonderzoek bij de Universiteit Leiden. Het duaal promotieprogramma van het Dual PhD Centre biedt professionals de kans een deel van hun werktijd te besteden aan het doen van promotieonderzoek.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Promotor: Prof.dr. M.A.G.J. Orrit

Machine Learning is becoming a more and more substantial technology for industry.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Promotor: A. Kros

Promotores: H. Schiessel, G.T. Barkema

Promotor: Prof.dr. M.K. Richardson

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Kijken naar cybercriminaliteit vanuit een criminologisch, juridisch, bestuurskundig en een technisch perspectief. De nieuwe bachelor Cybersecurity & Cybercrime vormt een antwoord op de groeiende vraag naar veelzijdige cyberprofessionals.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Dr. Joris Larik, universitair docent vergelijkend, EU- en internationaal recht bij LUC The Hague, is coauteur van het rapport 'UN 2.0: Ten Innovations for Global Governance 75 Years beyond San Francisco'.